Pls3 Gene Summary [Rat]
Predicted to enable actin filament binding activity. Predicted to be a structural constituent of presynaptic actin cytoskeleton. Involved in inner ear auditory receptor cell differentiation. Located in stereocilium. Human ortholog(s) of this gene implicated in congenital diaphragmatic hernia. Orthologous to human PLS3 (plastin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pls3 |
| Official Name | plastin 3 [Source:RGD Symbol;Acc:621409] |
| Ensembl ID | ENSRNOG00000027520 |
| Bio databases IDs | |
| Aliases | plastin 3 |
| Synonyms | BMND18, DIH5, plastin 3, plastin 3 (T-isoform), T-plastin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pls3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand, calcium binding motif
- Calponin homology domain
- structural constituent of cytoskeleton
- EF-hand domain pair
- EF hand
- calponin homology (CH) domain superfamily
- EFh
- structural molecule
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- X-linked diaphragmatic hernia type 5
- colorectal cancer with distant metastasis
- organismal death
- juvenile dermatomyositis
- gout
- osteoporosis
- Sézary syndrome
- Duchenne muscular dystrophy
- X-linked osteoporosis with fractures
role in cell
- growth
- size
- morphology
- organization
- reorganization
- sporulation
- reorganization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- apical compartment
- perinuclear region
- Plasma Membrane
- Mitochondria
- cytosol
- stereocilia
- apical cell surfaces
- basolateral membrane
- neuromuscular junctions
- filopodia
- plasma
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pls3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- actin filament network formation
- actin filament bundle assembly
- bone development
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- actin filament bundle
- cytosol
- actin filament
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- calcium ion binding