Gtf2f2 Gene Summary [Rat]
Enables RNA polymerase II general transcription initiation factor activity. Involved in RNA polymerase II preinitiation complex assembly and transcription elongation by RNA polymerase II. Part of transcription factor TFIIH holo complex. Orthologous to human GTF2F2 (general transcription factor IIF subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gtf2f2 |
| Official Name | general transcription factor IIF subunit 2 [Source:RGD Symbol;Acc:620772] |
| Ensembl ID | ENSRNOG00000029316 |
| Bio databases IDs | |
| Aliases | general transcription factor IIF subunit 2 |
| Synonyms | 1110031C13Rik, BTF4, general transcription factor IIF, polypeptide 2, general transcription factor IIF subunit 2, RAP30, TF2F2, TFIIF, TFIIF-beta, TFIIF-β |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gtf2f2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- TFIIF, beta subunit N-terminus
- RNA polymerase II binding domain
- Transcription initiation factor IIF, beta subunit
- protein binding
- general RNA polymerase II transcription factor
Pathways
Biological processes and signaling networks where the Gtf2f2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- expression in
- transcription in
- differentiation
- cell death
- JQ1-sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- microtubule cytoskeleton
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gtf2f2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- transcription initiation from RNA polymerase II promoter
- transcription elongation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- microtubule cytoskeleton
- transcription factor TFIIF complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- general RNA polymerase II transcription factor activity