Dusp8 Gene Summary [Rat]
Predicted to enable MAP kinase tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; and protein tyrosine/threonine phosphatase activity. Predicted to be involved in dephosphorylation; negative regulation of MAPK cascade; and signal transduction. Predicted to be active in cytoplasm. Orthologous to human DUSP8 (dual specificity phosphatase 8). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dusp8 |
| Official Name | dual specificity phosphatase 8 [Source:RGD Symbol;Acc:1306425] |
| Ensembl ID | ENSRNOG00000029394 |
| Bio databases IDs | |
| Aliases | dual specificity phosphatase 8 |
| Synonyms | 5530400B01RIK, C11orf81, dual specificity phosphatase 8, HB5, HVH-5, HVH8, M3/6, Nttp1, VH5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dusp8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein-tyrosine-phoshatase
- phosphoprotein phosphatase
- catalytic domain
- Rhodanese Homology Domain
- Rhodanese-like domain
- PTP_DSP_cys
- protein binding
- RHOD
- Protein tyrosine phosphatase, catalytic domain motif
- Dual specificity phosphatase, catalytic domain
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- phosphatase
- delta-like domain
Pathways
Biological processes and signaling networks where the Dusp8 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- peripheral T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- allergic asthma
role in cell
- expression in
- survival
- number
- quantity
- proliferation
- differentiation
- migration
- abnormal morphology
- colony formation by
- upregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dusp8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of MAPK cascade
- dephosphorylation
- peptidyl-tyrosine dephosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein tyrosine/threonine phosphatase activity
- MAP kinase tyrosine phosphatase activity
- phosphatase activity
- MAP kinase tyrosine/serine/threonine phosphatase activity
- myosin phosphatase activity