Gsta4 Gene Summary [Rat]
Enables toxic substance binding activity. Involved in several processes, including cellular response to lithium ion; response to herbicide; and response to zinc ion. Predicted to be located in cytosol and mitochondrion. Orthologous to human GSTA4 (glutathione S-transferase alpha 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gsta4 |
| Official Name | glutathione S-transferase alpha 4 [Source:RGD Symbol;Acc:1309970] |
| Ensembl ID | ENSRNOG00000030449 |
| Bio databases IDs | |
| Aliases | glutathione S-transferase alpha 4 |
| Synonyms | glutathione S-transferase alpha 4, glutathione S-transferase, alpha 4, Glutathione S-transferase, alpha 4, from rodents, Glutathione S-transferase Subunit 8, glutathione S-transferase α 4, glutathione S-transferase, α 4, Glutathione S-transferase, α 4, from rodents, GST, GST5.7, mGsta4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gsta4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glutathione S-transferase, C-terminal domain
- Glutathione S-transferase, N-terminal domain
- C-terminal, alpha helical domain of the Glutathione S-transferase family
- glutathione transferase
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- protein homodimerization
- enzyme
- identical protein binding
- toxin binding
Pathways
Biological processes and signaling networks where the Gsta4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- squamous cell cancer
- squamous-cell carcinoma
- papillomatosis
- papilloma
- infection by bacteria
- infection by Pseudomonas aeruginosa
role in cell
- production in
- transmembrane potential
- carbonylation in
- mitochondrial respiration in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- Mitochondria
- cytosol
- apical membrane
- basolateral membrane