Gzmm Gene Summary [Rat]
Enables serine-type peptidase activity. Predicted to be involved in apoptotic process and protein maturation. Predicted to act upstream of or within T cell mediated cytotoxicity. Predicted to be active in extracellular space. Orthologous to human GZMM (granzyme M). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gzmm |
| Official Name | granzyme M [Source:RGD Symbol;Acc:620022] |
| Ensembl ID | ENSRNOG00000030530 |
| Bio databases IDs | |
| Aliases | granzyme M |
| Synonyms | Granzyme M, granzyme M (lymphocyte met-ase 1), GRZ M, LMET1, lymphocyte met-ase 1, MET1, MMET-1, Serine protease l05175 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gzmm often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trypsin-like serine protease
- endopeptidase
- serine endopeptidase
- trypsin
- Tryp_SPc
- serine-type peptidase
- peptidase
- Domain of unknown function (DUF1986)
- Trypsin-like peptidase domain
- protein binding
Pathways
Biological processes and signaling networks where the Gzmm gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Waldenström macroglobulinemia
- diabetic nephropathy
- T-cell large granular lymphocytic leukemia
- tuberculoid leprosy
- endotoxicosis
- sporadic amyotrophic lateral sclerosis
- paroxysmal nocturnal hemoglobinuria
- chronic natural killer lymphoproliferative disorder
role in cell
- cell death
- apoptosis
- activation in
- transmembrane potential
- morphology
- development
- molecular cleavage in
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gzmm gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- innate immune response
- proteolysis
- apoptotic process
- killing of cells of other organism
- T cell mediated cytotoxicity
Cellular Component
Where in the cell the gene product is active
- membrane
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- serine-type endopeptidase activity
- serine-type peptidase activity