Slc52a2 Gene Summary [Rat]
Enables riboflavin transmembrane transporter activity. Involved in riboflavin transport. Located in plasma membrane. Human ortholog(s) of this gene implicated in Brown-Vialetto-Van Laere syndrome 2 and riboflavin deficiency. Orthologous to human SLC52A1 (solute carrier family 52 member 1) and SLC52A2 (solute carrier family 52 member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc52a2 |
| Official Name | solute carrier family 52 member 2 [Source:RGD Symbol;Acc:1560410] |
| Ensembl ID | ENSRNOG00000032561 |
| Bio databases IDs | |
| Aliases | solute carrier family 52 member 2 |
| Synonyms | 2010003P03Rik, BVVLS2, D15Ertd747e, GPCR41, GPCR42, GPR172A, Gpr172b, hRFT3, HuPAR-1, LOC103692940, mRFT1, PAR1, PAR2, RFT1, RFT3, RFVT2, RGD1560410, rRFT1, solute carrier family 52 member 2, solute carrier protein 52, member 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc52a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signaling receptor activity
- protein binding
- organic anion transporter
- transporter
- Protein of unknown function (DUF1011)
Pathways
Biological processes and signaling networks where the Slc52a2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- Brown-Vialetto-Van Laere syndrome type 2
- idiopathic hypersomnia
- alcoholism
- chronic fatigue syndrome
- narcolepsy with cataplexy
- narcolepsy
- vocal tremor
- binge eating disorder
- fibromyalgia
role in cell
- injury
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc52a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- riboflavin transport
- riboflavin metabolic process
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- viral receptor activity
- riboflavin transporter activity