Sp110 Gene Summary [Rat]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of apoptotic process and response to bacterium. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in hepatic venoocclusive disease with immunodeficiency and tuberculosis. Orthologous to human SP110 (SP110 nuclear body protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sp110 |
| Official Name | SP110 nuclear body protein [Source:RGD Symbol;Acc:1310173] |
| Ensembl ID | ENSRNOG00000033747 |
| Bio databases IDs | |
| Aliases | SP110 nuclear body protein |
| Synonyms | 5031415C07RIK, 5830484A20RIK, IFI41, IFI75, IPR1, NUCLEAR PHOSPHOPROTEIN, SP110 nuclear body protein, VODI |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sp110 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cell division protein FtsN
- KDWK domain
- PHD zinc finger
- SP100-like domain
- HCV core protein binding domain
- PHD finger superfamily
- Bromodomain
- SAND domain
- HSR domain
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tuberculosis
- hepatic veno-occlusive disease with immunodeficiency
- chronic lymphocytic leukemia
- peripheral T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- infection by HIV-1
- productive infection by HIV-1
role in cell
- expression in
- growth
- damage in
- downregulation in
- recruitment in
- upregulation in
- missegregation in
- homologous recombination repair in
- replication in
- missegregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sp110 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- metal ion binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity