Aldh3a1 Gene Summary [Rat]
Enables 3-chloroallyl aldehyde dehydrogenase activity. Involved in several processes, including response to cAMP; response to glucocorticoid; and response to hypoxia. Located in cytosol. Human ortholog(s) of this gene implicated in arteriosclerosis. Orthologous to human ALDH3A1 (aldehyde dehydrogenase 3 family member A1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aldh3a1 |
| Official Name | aldehyde dehydrogenase 3 family, member A1 [Source:RGD Symbol;Acc:2088] |
| Ensembl ID | ENSRNOG00000002331 |
| Bio databases IDs | |
| Aliases | aldehyde dehydrogenase 3 family, member A1 |
| Synonyms | Ahd-4, AHDC, Aldehyde Dehydrogenase, aldehyde dehydrogenase 3 family member A1, aldehyde dehydrogenase 3 family, member A1, aldehyde dehydrogenase family 3, subfamily A1, Aldh, ALDH3, ALDHIII, T-aldh |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aldh3a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Aldehyde dehydrogenase family
- Acyl-CoA reductase (LuxC)
- aldehyde dehydrogenase
- benzaldehyde dehydrogenase (NAD)
- enzyme
- protein binding
- delta-1-pyrroline-5-carboxylate dehydrogenase (PutA C-terminal domain)
- alcohol dehydrogenase (NADP)
- NAD(P)+-dependent aldehyde dehydrogenase superfamily
- aldehyde dehydrogenase [NAD(P)]
- aldehyde dehydrogenase (NAD)
- methylmalonic acid semialdehyde dehydrogenase
- aldehyde or oxo group:NAD or NADP oxidoreductase
Pathways
Biological processes and signaling networks where the Aldh3a1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- neoplasia
- organismal death
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- gastric adenocarcinoma
- gastric epithelial cancer
- keratoconus
- hemorrhagic cystitis
- astigmatism
role in cell
- expression in
- accumulation in
- apoptosis
- proliferation
- ferroptosis
- activation in
- migration
- cell cycle progression
- cell viability
- peroxidation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Aldh3a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular aldehyde metabolic process
- lipid metabolic process
- xenobiotic metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- cytosol
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- aldehyde dehydrogenase (NAD) activity
- 3-chloroallyl aldehyde dehydrogenase activity
- protein binding
- aldehyde dehydrogenase [NAD(P)+] activity
- benzaldehyde dehydrogenase (NAD+) activity
- alcohol dehydrogenase (NADP+) activity