Suv39h1l1 Gene Summary [Rat]
Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; histone H3K9 trimethyltransferase activity; and histone H3K9me2 methyltransferase activity. Involved in response to amphetamine and response to nutrient levels. Predicted to be located in nucleolus and rDNA heterochromatin. Predicted to be part of eNoSc complex. Predicted to be active in nucleus. Biomarker of pre-malignant neoplasm. Orthologous to human SUV39H1 (SUV39H1 histone lysine methyltransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Suv39h1l1 |
| Official Name | suppressor of variegation 3-9 homolog 1 (Drosophila)-like 1 [Source:RGD Symbol;Acc:1565028] |
| Ensembl ID | ENSRNOG00000039576 |
| Bio databases IDs | |
| Aliases | suppressor of variegation 3-9 homolog 1 (Drosophila)-like 1 |
| Synonyms | DXHXS7466e, H3-K9-HMTase 1, KMT1A, MG44, mIS6, RGD1565028, suppressor of variegation 3-9 1, SUV39H, SUV39H1 histone lysine methyltransferase, Suv39h1l1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Suv39h1l1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Chromatin organization modifier domain
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
- nucleic acid binding
- chromatin binding
- enzyme
- protein binding
- sequence-specific DNA binding
- S-adenosylmethionine-dependent methyltransferase
- histone lysine N-methyltransferase activity (H3-K9 specific)
- Pre-SET motif
- protein methyltransferase
- histone methyltransferase
- CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
- double-stranded DNA binding
- SET domain
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
- Chromo (CHRromatin organization MOdifier) domain
- N-terminal to some SET domains
Pathways
Biological processes and signaling networks where the Suv39h1l1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- acute myeloid leukemia
- tumorigenesis
- KMT2A rearrangement positive acute myeloid leukemia
role in cell
- proliferation
- binding
- expression in
- formation
- production in
- cell viability
- binding in
- growth
- transcription in
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- heterochromatin
- centromeric region
- nuclear foci
- chromosome
- nucleoplasm
- nucleoli
- nuclear bodies
- chromosomal arms
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Suv39h1l1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell cycle
- regulation of transcription by glucose
- rRNA processing
- chromatin organization
- response to DNA damage stimulus
- circadian rhythm
- cellular response to glucose starvation
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- chromatin silencing at rDNA
- energy homeostasis
- cell differentiation
- cellular response to hypoxia
- methylation
Cellular Component
Where in the cell the gene product is active
- heterochromatin
- nucleus
- cytoplasmic vesicle
- rDNA heterochromatin
- chromosome, centromeric region
- nucleolus
- nuclear lamina
- plasma membrane
- chromatin silencing complex
- condensed nuclear chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- histone methyltransferase activity
- histone methyltransferase activity (H3-K9 specific)
- transcription regulatory region sequence-specific DNA binding
- chromatin binding
- S-adenosylmethionine-dependent methyltransferase activity