Ccne1 Gene Summary [Rat]
Enables protein kinase binding activity. Involved in several processes, including response to corticosterone; response to progesterone; and response to vitamin E. Located in centrosome. Biomarker of hepatocellular carcinoma; hypertension; liver cancer; and ovarian carcinoma. Human ortholog(s) of this gene implicated in breast adenocarcinoma. Orthologous to human CCNE1 (cyclin E1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccne1 |
| Official Name | cyclin E1 [Source:RGD Symbol;Acc:2294] |
| Ensembl ID | ENSRNOG00000014786 |
| Bio databases IDs | |
| Aliases | cyclin E1 |
| Synonyms | CCNE, CycE1, CYCLE, cyclin E, Cyclin E1, pCCNE1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ccne1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- cyclin box
- binding protein
- protein kinase binding
- Cyclin box fold superfamily
- intracellular domain
- Cyclin, N-terminal domain
- protein binding
- domain present in cyclins, TFIIB and Retinoblastoma
- cyclin-dependent protein kinase regulator
Pathways
Biological processes and signaling networks where the Ccne1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Antiproliferative Role of TOB in T Cell Signaling
- Aryl Hydrocarbon Receptor Signaling
- Cell Cycle Regulation by BTG Family Proteins
- Cyclins and Cell Cycle Regulation
- DNA damage-induced 14-3-3σ Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Estrogen-mediated S-phase Entry
- GADD45 Signaling
- Glioblastoma Multiforme Signaling
- HER-2 Signaling in Breast Cancer
- Molecular Mechanisms of Cancer
- Pancreatic Adenocarcinoma Signaling
- Prostate Cancer Signaling
- Regulation of Cellular Mechanics by Calpain Protease
- Serotonin Receptor Signaling
- Small Cell Lung Cancer Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- cancer
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
- epithelial cancer
- epithelial neoplasia
- head and neck neuroendocrine neoplasia
role in cell
- expression in
- binding in
- activation
- phosphorylation in
- quantity
- apoptosis
- growth
- migration
- amplification
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- perinuclear region
- centrosome
- cytosol
- nuclear foci
- nucleoplasm
- nucleoli
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ccne1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- cell division
- DNA-dependent DNA replication initiation
- positive regulation of G1/S transition of mitotic cell cycle
- regulation of protein localization
- G1/S transition of mitotic cell cycle
- Wnt receptor signaling pathway
- telomere maintenance
- protein phosphorylation
- synapsis
- regulation of cyclin-dependent protein kinase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cyclin E1-CDK2 complex
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- cyclin-dependent protein kinase regulator activity
- kinase activity