Actr2 Gene Summary [Rat]
Enables cytoskeletal protein binding activity. Involved in several processes, including cellular response to trichostatin A; positive regulation of dendritic spine morphogenesis; and response to ethanol. Located in lamellipodium and podosome core. Is active in postsynapse. Orthologous to human ACTR2 (actin related protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Actr2 |
| Official Name | actin related protein 2 [Source:RGD Symbol;Acc:1310826] |
| Ensembl ID | ENSRNOG00000004959 |
| Bio databases IDs | |
| Aliases | actin related protein 2 |
| Synonyms | 4921510D23Rik, Actin-like protein 2, actin related protein 2, ARP2, ARP2 actin related protein 2 homolog, D6Ertd746e |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Actr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- cytoskeletal protein binding
- structural constituent of cytoskeleton
- Actin
- protein binding
- ASKHA_ATPase-like
Pathways
Biological processes and signaling networks where the Actr2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- Axonal Guidance Signaling
- CD28 Signaling in T Helper Cells
- Cdc42 Signaling
- Clathrin-mediated Endocytosis Signaling
- Ephrin Receptor Signaling
- Epithelial Adherens Junction Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- fMLP Signaling in Neutrophils
- Integrin Signaling
- Phagosome Formation
- Rac Signaling
- Reelin Signaling in Neurons
- Regulation of Actin-based Motility by Rho
- Remodeling of Epithelial Adherens Junctions
- RhoA Signaling
- RhoGDI Signaling
- Signaling by Rho Family GTPases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ankylosing spondylitis
- infection by murine hepatitis virus
- Parkinson disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- organismal death
- sacroiliitis
- diffuse large B-cell lymphoma
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
role in cell
- transport in
- quantity
- survival
- formation
- morphology
- organization
- phagocytosis by
- response by
- behavior by
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- ficolin-1-rich granule lumen
- azurophil granule lumen
- Cytoplasm
- cell surface
- Extracellular Space
- postsynaptic region
- actin cytoskeleton
- cell cortex
- Nucleus
- Mitochondria
- cytosol
- nucleoli
- synaptic vesicles
- cell membrane leading edge
- exosomes
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Actr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of lamellipodium assembly
- regulation of double-strand break repair via nonhomologous end joining
- cilium morphogenesis
- establishment or maintenance of cell polarity
- asymmetric cell division
- positive regulation of transcription from RNA polymerase II promoter
- spindle localization
- cytoplasmic transport
- Arp2/3 complex-mediated actin nucleation
- cellular response to interferon-gamma
- meiotic chromosome movement towards spindle pole
- cytokinesis after meiosis
Cellular Component
Where in the cell the gene product is active
- site of double-strand break
- extracellular region
- cell projection
- Arp2/3 protein complex
- nucleus
- extracellular vesicular exosome
- focal adhesion
- cytoplasm
- cell cortex
- membrane
- actin cytoskeleton
- cytosol
- azurophil granule lumen
- actin cap
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- ATP binding
- protein binding
- structural constituent of cytoskeleton