LOC108348172 Gene Summary [Rat]
Enables endopeptidase inhibitor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to act upstream of or within peptide hormone processing; response to cold; and response to dietary excess. Located in extracellular space. Used to study obesity. Orthologous to human PCSK1N (proprotein convertase subtilisin/kexin type 1 inhibitor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | LOC108348172 |
| Official Name | proSAAS [Source:RGD Symbol;Acc:11409911] |
| Ensembl ID | ENSRNOG00000046021 |
| Bio databases IDs | |
| Aliases | proSAAS |
| Synonyms | BigLEN, KEP, lLEN, LOC100911286, LOC108348172, PAN3, PEN, PEN19, PEN20, proprotein convertase subtilisin/kexin type 1 inhibitor, PROSAAS, SAAS, SAASCT, SCG8, SgVIII |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Loc108348172 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- endopeptidase inhibitor
- serine protease inhibitor activity
- ProSAAS precursor
- protein binding
- receptor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- non-insulin-dependent diabetes mellitus
- adult-onset obesity
role in cell
- phosphorylation in
- accumulation in
- activation in
- proliferation
- outgrowth
- cell survival
- flux in
- outgrowth in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- perinuclear region
- trans Golgi network
- secretory vesicles
- secretory granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Loc108348172 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cold
- neuropeptide signaling pathway
- peptide hormone processing
- response to dietary excess
Cellular Component
Where in the cell the gene product is active
- extracellular space
- trans-Golgi network
- secretory granule
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- endopeptidase inhibitor activity
- receptor binding