C5 Gene Summary [Rat]
Enables C5a anaphylatoxin chemotactic receptor binding activity. Involved in several processes, including intracellular calcium ion homeostasis; leukocyte migration involved in inflammatory response; and negative regulation of catecholamine secretion. Located in extracellular space. Used to study adult respiratory distress syndrome; asthma; and neutropenia. Biomarker of brain edema and fetal alcohol spectrum disorder. Human ortholog(s) of this gene implicated in several diseases, including complement component 5 deficiency; liver cirrhosis; neutropenia; paroxysmal nocturnal hemoglobinuria; and pneumonia. Orthologous to human C5 (complement C5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | C5 |
| Official Name | complement C5 [Source:RGD Symbol;Acc:2237] |
| Ensembl ID | ENSRNOG00000018899 |
| Bio databases IDs | |
| Aliases | complement C5 |
| Synonyms | C5a, C5D, Complement C5, Complement Component C5/C5a, complement pathway protein C5, CPAMD4, ECLZB, haemolytic complement, Hc, He, hemolytic complement, Hfib2, RGD1561905 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat C5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Alpha-2-macroglobulin bait region domain
- Macroglobulin domain MG4
- G-protein-coupled receptor binding
- A-macroglobulin receptor binding domain
- protein binding
- receptor binding
- cytokine
- Macroglobulin domain MG3
- NTR_like
- ISOPREN_C2_like
- chemokine
- A-macroglobulin TED domain
- Macroglobulin domain MG1
- extracellular loop
- ANATO
- Alpha-2-macroglobulin family
- MG2 domain
Pathways
Biological processes and signaling networks where the C5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pain
- asthma
- schizophrenia
- septic shock
- severe sepsis
- fibrosis
- plasma cell myeloma
- atypical hemolytic uremic syndrome
- airway hyperresponsiveness
- autoimmune disease
role in cell
- expression in
- phosphorylation in
- apoptosis
- proliferation
- binding
- activation in
- activity
- migration
- differentiation
- chemotaxis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- Nucleus
- apical cell surfaces
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat C5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- complement activation, alternative pathway
- chemotaxis
- inflammatory response
- G-protein coupled receptor signaling pathway
- complement activation, classical pathway
- killing of cells of other organism
- cell surface receptor signaling pathway
- positive regulation of chemokine production
- negative regulation of macrophage chemotaxis
- positive regulation vascular endothelial growth factor production
- cell chemotaxis
Cellular Component
Where in the cell the gene product is active
- membrane attack complex
- extracellular space
- extracellular vesicular exosome
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- endopeptidase inhibitor activity
- chemokine activity
- receptor binding