Aplp1 Gene Summary [Rat]
Predicted to enable adrenergic receptor binding activity and identical protein binding activity. Predicted to be involved in cellular response to norepinephrine stimulus; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; and nervous system development. Predicted to act upstream of or within several processes, including cytosolic mRNA polyadenylation; extracellular matrix organization; and regulation of translation. Predicted to be located in membrane; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be active in Golgi apparatus and plasma membrane. Orthologous to human APLP1 (amyloid beta precursor like protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aplp1 |
| Official Name | amyloid beta precursor like protein 1 [Source:RGD Symbol;Acc:69257] |
| Ensembl ID | ENSRNOG00000020851 |
| Bio databases IDs | |
| Aliases | amyloid beta precursor like protein 1 |
| Synonyms | amyloid beta precursor like protein 1, amyloid β precursor like protein 1, APLP, Aplp1 retired, RGD1561211 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aplp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- JMTM_Notch_APP
- amyloid A4
- carbohydrate recognition domain
- ectodomain
- G-protein-coupled receptor binding
- Beta-amyloid precursor protein C-terminus
- E2 domain of amyloid precursor protein
- protein binding
- identical protein binding
- Amyloid A4 N-terminal heparin-binding
- Flagellar assembly protein FliH
- Copper-binding of amyloid precursor, CuBD
- NPXY motif
- growth factor domain
- cytoplasmic domain
- copper binding domain
- HrpE/YscL/FliH and V-type ATPase subunit E
- intracellular domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- endometriosis
- dysplasia
- Huntington disease
- chronic fatigue syndrome
role in cell
- quantity
- accumulation in
- binding
- internalization
- organization
- translation in
- uptake
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- synaptic plasma membrane fractions
- cell surface
- perinuclear region
- cellular membrane
- Plasma Membrane
- vesicles
- Golgi Apparatus
- cell-cell contacts
- membrane ruffles
- Golgi membrane
- nucleoplasm
- perinuclear space
- postsynaptic density
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Aplp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- central nervous system development
- forebrain development
- axonogenesis
- apoptotic process
- extracellular matrix organization
- nervous system development
- cell adhesion
- cellular response to norepinephrine stimulus
- endocytosis
- organ morphogenesis
Cellular Component
Where in the cell the gene product is active
- basement membrane
- perinuclear region of cytoplasm
- Golgi apparatus
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- transition metal ion binding
- protein binding
- alpha-2B adrenergic receptor binding
- alpha-2C adrenergic receptor binding
- heparin binding
- alpha-2A adrenergic receptor binding