Ncstn Gene Summary [Rat]
Enables peptidase activity. Involved in cerebellum development and protein processing. Located in several cellular components, including cytoplasmic vesicle; lysosomal membrane; and sarcolemma. Part of protein-containing complex. Is active in presynaptic membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; hidradenitis suppurativa; and schizophrenia. Orthologous to human NCSTN (nicastrin). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ncstn |
| Official Name | nicastrin [Source:RGD Symbol;Acc:631418] |
| Ensembl ID | ENSRNOG00000005355 |
| Bio databases IDs | |
| Aliases | nicastrin |
| Synonyms | 9430068N19Rik, APH2, ATAG1874, D1Dau13e, Kiaa0253, mKIAA0253, NCT, NICASTRIN |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ncstn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- growth factor receptor binding
- Nicastrin small lobe
- peptidase
- protein binding activity, bridging
- enzyme
- enzyme regulator activity
- protein binding
- protease activator
- Peptidase family M28
- aspartic endopeptidase, intramembrane cleaving
- ATPase binding
- endopeptidase
- Zinc peptidases M18, M20, M28, and M42
- lumenal domain
- transmembrane domain
- cytosolic tail domain
Pathways
Biological processes and signaling networks where the Ncstn gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Amyloid Processing
- Docosahexaenoic Acid (DHA) Signaling
- Ephrin A Signaling
- ErbB4 Signaling
- Mitochondrial Dysfunction
- Molecular Mechanisms of Cancer
- Neuroinflammation Signaling Pathway
- Notch Signaling
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Th1 and Th2 Activation Pathway
- Th1 Pathway
- Th2 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- familial acne inversa type 1
- chronic myelomonocytic leukemia
- organismal death
- hypopigmentation
- tumorigenesis
- growth failure
- urothelial bladder carcinoma
- transitional cell bladder cancer
- failure of heart looping
role in cell
- expression in
- apoptosis
- proliferation
- accumulation
- signaling in
- binding in
- survival
- function
- development
- regulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- raft fractions
- membrane fraction
- mitochondrial fraction
- pH resistant lipid raft fraction
- outer limiting lysosomal membrane
- endoplasmic reticulum mitochondria contact site
- cell surface
- perinuclear region
- cellular membrane
- Nucleus
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- secretory granule membrane
- ER-to-Golgi intermediate compartment
- presynaptic membrane
- synaptic membrane
- lysosome membrane
- endosomal membrane
- synaptic vesicles
- neurites
- synaptosomes
- sarcolemma
- early endosomes
- cytoplasmic vesicles
- GLUT4 vesicles
- perikaryon
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ncstn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of long-term synaptic potentiation
- dopamine receptor signaling pathway
- myeloid cell homeostasis
- glutamate receptor signaling pathway
- learning or memory
- central nervous system myelination
- epithelial cell proliferation
- cellular response to calcium ion
- positive regulation of endopeptidase activity
- neuron apoptotic process
- beta-amyloid formation
- amyloid precursor protein catabolic process
- Notch receptor processing
- cerebellum development
- membrane protein intracellular domain proteolysis
- amyloid precursor protein metabolic process
- amyloid precursor protein biosynthetic process
- positive regulation of amyloid precursor protein biosynthetic process
- Notch signaling pathway
- membrane protein ectodomain proteolysis
- proteolysis
- T cell proliferation
- protein processing
- adult behavior
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- synaptic vesicle
- endoplasmic reticulum
- Golgi membrane
- Golgi apparatus
- plasma membrane
- lysosomal membrane
- endoplasmic reticulum membrane
- early endosome
- extracellular vesicular exosome
- focal adhesion
- melanosome
- sarcolemma
- membrane
- gamma-secretase complex
- endosome membrane
- azurophil granule membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- growth factor receptor binding
- protein binding, bridging
- aspartic endopeptidase activity, intramembrane cleaving
- ATPase binding