Sin3b Gene Summary [Rat]
Predicted to be involved in negative regulation of NF-kappaB transcription factor activity and positive regulation of gene expression. Predicted to be located in cytosol and nucleolus. Orthologous to human NWD1 (NACHT and WD repeat domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sin3b |
| Official Name | SIN3 transcription regulator family member B [Source:RGD Symbol;Acc:1587989] |
| Ensembl ID | ENSRNOG00000048622 |
| Bio databases IDs | |
| Aliases | SIN3 transcription regulator family member B |
| Synonyms | 2810430C10Rik, Msin3b, SIN3B long isoform, SIN3 transcription regulator family member B, transcriptional regulator, SIN3B (yeast) |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sin3b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Histone deacetylase (HDAC) interacting
- transcription co-repressor
- C-terminal domain of Sin3a protein
- Sin3 family co-repressor
- histone deacetylase binding domain
- chromatin binding
- protein binding
- Paired amphipathic helix repeat
Pathways
Biological processes and signaling networks where the Sin3b gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- growth failure
role in cell
- expression in
- apoptosis
- differentiation
- formation
- senescence
- number
- formation in
- cell viability
- degradation in
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- autosome
- Cytoplasm
- chromosome
- nucleoplasm
- sex chromatin
- X chromosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sin3b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- XY body
- Y chromosome
- X chromosome
- cytoplasm
- autosome
- chromatin
- Sin3-type complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription corepressor activity
- chromatin binding