Sgk3 Gene Summary [Rat]
Predicted to enable molecular adaptor activity; potassium channel regulator activity; and protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. Predicted to be located in cytoplasmic vesicle. Orthologous to several human genes including SGK3 (serum/glucocorticoid regulated kinase family member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sgk3 |
| Official Name | serum/glucocorticoid regulated kinase family, member 3 [Source:RGD Symbol;Acc:620242] |
| Ensembl ID | ENSRNOG00000049052 |
| Bio databases IDs | |
| Aliases | serum/glucocorticoid regulated kinase family, member 3 |
| Synonyms | 2510015P22Rik, A330005P07Rik, CISK, fy, fz, LOC103692278, serum/glucocorticoid regulated kinase 3, serum/glucocorticoid regulated kinase family member 3, serum/glucocorticoid regulated kinase family, member 3, SGK2, SGKL |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sgk3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein kinase C terminal domain
- Protein tyrosine and serine/threonine kinase
- potassium channel regulator
- sodium channel regulator
- chloride channel regulator
- protein binding
- Protein kinase domain
- calcium channel regulator
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Extension to Ser/Thr-type protein kinases
- The Phox Homology domain, a phosphoinositide binding module
- Tyrosine kinase, catalytic domain
- PX domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- breast cancer
- tumorigenesis
- melanoma
- melanoma cancer
role in cell
- apoptosis
- expression in
- phosphorylation in
- proliferation
- activation in
- degradation in
- migration
- growth
- survival
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- endosomes
- vesicles
- membrane compartment
- cytosol
- microdomains
- early endosomes
- perinuclear vesicles
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sgk3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- regulation of cell growth
- regulation of cell migration
- peptidyl-serine phosphorylation
- protein phosphorylation
- regulation of cell proliferation
- intracellular signal transduction
- regulation of sequence-specific DNA binding transcription factor activity
Cellular Component
Where in the cell the gene product is active
- early endosome
- cytosol
- recycling endosome
Molecular Function
What the gene product does at the molecular level
- sodium channel regulator activity
- ATP binding
- chloride channel regulator activity
- protein binding
- phosphatidylinositol binding
- protein kinase activity
- protein serine/threonine kinase activity
- calcium channel regulator activity
- potassium channel regulator activity