SGK3 Gene Summary [Human]
This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | SGK3 |
| Official Name | serum/glucocorticoid regulated kinase family member 3 [Source:HGNC Symbol;Acc:HGNC:10812] |
| Ensembl ID | ENSG00000104205 |
| Bio databases IDs | |
| Aliases | serum/glucocorticoid regulated kinase family member 3 |
| Synonyms | 2510015P22Rik, A330005P07Rik, CISK, fy, fz, LOC103692278, serum/glucocorticoid regulated kinase 3, serum/glucocorticoid regulated kinase family member 3, serum/glucocorticoid regulated kinase family, member 3, SGK2, SGKL |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SGK3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein kinase C terminal domain
- Protein tyrosine and serine/threonine kinase
- potassium channel regulator
- sodium channel regulator
- chloride channel regulator
- protein binding
- Protein kinase domain
- calcium channel regulator
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Extension to Ser/Thr-type protein kinases
- The Phox Homology domain, a phosphoinositide binding module
- Tyrosine kinase, catalytic domain
- PX domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- breast cancer
- tumorigenesis
- melanoma
- melanoma cancer
role in cell
- apoptosis
- expression in
- phosphorylation in
- proliferation
- activation in
- degradation in
- migration
- growth
- survival
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- endosomes
- vesicles
- membrane compartment
- cytosol
- microdomains
- early endosomes
- perinuclear vesicles
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SGK3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- regulation of cell growth
- regulation of cell migration
- peptidyl-serine phosphorylation
- protein phosphorylation
- regulation of cell proliferation
- intracellular signal transduction
- regulation of sequence-specific DNA binding transcription factor activity
Cellular Component
Where in the cell the gene product is active
- early endosome
- cytosol
- recycling endosome
Molecular Function
What the gene product does at the molecular level
- sodium channel regulator activity
- ATP binding
- chloride channel regulator activity
- protein binding
- phosphatidylinositol binding
- protein kinase activity
- protein serine/threonine kinase activity
- calcium channel regulator activity
- potassium channel regulator activity