Snrpd3 Gene Summary [Rat]
Enables U1 snRNP binding activity. Predicted to be involved in spliceosomal snRNP assembly. Predicted to act upstream of or within protein methylation. Part of U1 snRNP. Human ortholog(s) of this gene implicated in systemic lupus erythematosus. Orthologous to human SNRPD3 (small nuclear ribonucleoprotein D3 polypeptide). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Snrpd3 |
| Official Name | small nuclear ribonucleoprotein D3 polypeptide [Source:RGD Symbol;Acc:1597573] |
| Ensembl ID | ENSRNOG00000050410 |
| Bio databases IDs | |
| Aliases | small nuclear ribonucleoprotein D3 polypeptide |
| Synonyms | 1700043E15Rik, 2310009E13RIK, small nuclear ribonucleoprotein D3, small nuclear ribonucleoprotein D3 polypeptide, SMALL NUCLEAR RIBONUCLEOPROTEIN D3 POLYPEPTIDE 18KDA, SMD3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Snrpd3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- snRNA binding
- Sm and related proteins
- ribonucleoprotein binding
- enzyme binding
- tail domain
- protein binding
- glycine arginine rich domain
- RNA binding
Pathways
Biological processes and signaling networks where the Snrpd3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- chronic lymphocytic leukemia
- tumorigenesis
- non-small cell lung cancer
- migraines
- infection by HIV-1
role in cell
- expression in
- apoptosis
- cell death
- cell viability
- splicing by
- alternative splicing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- catalytic step 2 spliceosome
- Cytoplasm
- cytosol
- spliceosomes
- nucleoplasm
- nucleoli
- nuclear bodies
- interchromatin granule clusters
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Snrpd3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- protein methylation
- nuclear mRNA splicing, via spliceosome
- spliceosomal snRNP assembly
Cellular Component
Where in the cell the gene product is active
- nuclear body
- U5 snRNP
- spliceosomal complex
- U2-type spliceosomal complex
- U7 snRNP
- telomerase holoenzyme complex
- U2 snRNP
- U1 snRNP
- nucleoplasm
- U4 snRNP
- commitment complex
- U12-type spliceosomal complex
- nucleus
- pICln-Sm protein complex
- catalytic step 2 spliceosome
- precatalytic spliceosome
- methylosome
- SMN-Sm protein complex
- U4/U6 x U5 tri-snRNP complex
- U2-type catalytic step 2 spliceosome
- cytosol
- U2-type precatalytic spliceosome
- small nuclear ribonucleoprotein complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- telomeric RNA binding
- histone pre-mRNA DCP binding
- U7 snRNA binding
- enzyme binding