Aqp5 Gene Summary [Rat]
Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Aqp5 |
| Official Name | aquaporin 5 [Source:RGD Symbol;Acc:2144] |
| Ensembl ID | ENSRNOG00000051970 |
| Bio databases IDs | |
| Aliases | aquaporin 5 |
| Synonyms | aquaporin 5, PPKB |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aqp5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MIP
- protein binding
- identical protein binding
- water channel
- transporter
Pathways
Biological processes and signaling networks where the Aqp5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- corneal neovascularization
- tumorigenesis
- Bothnia type palmoplantar keratoderma
- growth failure
- diabetic nephropathy
- corneal opacity
- bronchoconstriction
role in cell
- expression in
- cellular infiltration by
- proliferation
- migration
- quantity
- assembly
- regulatory volume decrease
- volume
- localization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cytoplasmic vesicle membrane
- apical compartment
- cellular membrane
- Endoplasmic Reticulum
- basal cell surfaces
- apical cell surfaces
- basolateral cell surfaces
- apical membrane
- basolateral membrane
- basal membrane
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Aqp5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- water transport
- camera-type eye morphogenesis
- transmembrane transport
- protein homotetramerization
- saliva secretion
- cellular hypotonic response
- carbon dioxide transport
- odontogenesis
- pancreatic juice secretion
Cellular Component
Where in the cell the gene product is active
- basal plasma membrane
- cytoplasmic vesicle membrane
- extracellular vesicular exosome
- microvillus
- endoplasmic reticulum
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- water channel activity