Klri1 Gene Summary [Rat]
Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in positive regulation of natural killer cell mediated cytotoxicity and stimulatory C-type lectin receptor signaling pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klri1 |
| Official Name | killer cell lectin-like receptor family I member 1 [Source:RGD Symbol;Acc:1359344] |
| Ensembl ID | ENSRNOG00000052803 |
| Bio databases IDs | |
| Aliases | killer cell lectin-like receptor family I member 1 |
| Synonyms | CD159c, killer cell lectin like receptor C2, killer cell lectin-like receptor family I member 1, Klri1, NKG2-C |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Klri1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signaling receptor activity
- binding protein
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- ectodomain
- transmembrane domain
- Lectin C-type domain
- antigen binding
- protein binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Klri1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Klri1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of natural killer cell activation
- cellular defense response
- natural killer cell mediated immunity
- signal transduction
- adaptive immune response
- positive regulation of natural killer cell degranulation
- stimulatory C-type lectin receptor signaling pathway
- positive regulation of natural killer cell mediated cytotoxicity
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- MHC class I protein complex binding
- transmembrane signaling receptor activity
- protein binding
- carbohydrate binding