Klrd1 Gene Summary [Rat]
Predicted to enable HLA-E specific inhibitory MHC class Ib receptor activity; MHC protein complex binding activity; and protein antigen binding activity. Predicted to be involved in natural killer cell mediated immunity; regulation of leukocyte mediated cytotoxicity; and stimulatory C-type lectin receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Orthologous to human KLRD1 (killer cell lectin like receptor D1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klrd1 |
| Official Name | killer cell lectin like receptor D1 [Source:RGD Symbol;Acc:2978] |
| Ensembl ID | ENSRNOG00000060246 |
| Bio databases IDs | |
| Aliases | killer cell lectin like receptor D1 |
| Synonyms | CD94, killer cell lectin like receptor D1, NKG2B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Klrd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signaling receptor activity
- binding protein
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- MHC protein binding
- Lectin C-type domain
- antigen binding
- protein binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Klrd1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- early-onset preeclampsia
- septic shock
- Tourette syndrome
- chronic natural killer lymphoproliferative disorder
- idiopathic scoliosis
- idiopathic pulmonary fibrosis
- aggressive NK-cell leukemia
role in cell
- expression in
- cell death
- activation
- cytotoxicity
- recognition
- cytolysis
- stimulation
- lysis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Klrd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of natural killer cell activation
- natural killer cell mediated immunity
- adaptive immune response
- negative regulation of T cell mediated cytotoxicity
- cell surface receptor signaling pathway
- negative regulation of natural killer cell mediated cytotoxicity
- positive regulation of natural killer cell mediated cytotoxicity
- stimulatory C-type lectin receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- MHC class I protein complex binding
- transmembrane signaling receptor activity
- protein binding
- MHC class Ib protein binding, via antigen binding groove
- carbohydrate binding