Cyp2c11 Gene Summary [Rat]
Enables arachidonate 11,12-epoxygenase activity; arachidonate 14,15-epoxygenase activity; and testosterone 16-alpha-hydroxylase activity. Involved in epoxygenase P450 pathway and icosanoid biosynthetic process. Located in endoplasmic reticulum membrane. Biomarker of depressive disorder; end stage renal disease; and hypertension. Orthologous to human CYP2C18 (cytochrome P450 family 2 subfamily C member 18). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyp2c11 |
| Official Name | cytochrome P450, subfamily 2, polypeptide 11 [Source:RGD Symbol;Acc:2469] |
| Ensembl ID | ENSRNOG00000052810 |
| Bio databases IDs | |
| Aliases | cytochrome P450, subfamily 2, polypeptide 11 |
| Synonyms | 2010301M18Rik, 2210009K14Rik, Cyp2c, Cyp2c11, Cyp2c11l, Cyp2c4, Cyp2c65, Cyp2c66, Cyp2c9, CYP2CII, cytochrome P450, family 2, subfamily c, polypeptide 65, cytochrome P450, family 2, subfamily c, polypeptide 66, cytochrome P450, subfamily 2, polypeptide 11, Hexobarbital hydroxylase, LOC100911826, p450 2c29, Progesterone 2alpha hydroxylase, RGD: 632285 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cyp2c11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- testosterone 16-alpha-hydroxylase
- arachidonic acid 11,12-epoxygenase
- arachidonic acid 14,15-epoxygenase
- oxidoreductase
- enzyme
- steroid hydroxylase
- CH2 group oxidoreductase
- arachidonic acid epoxygenase
- cytochrome P450 (CYP) superfamily
- Cytochrome P450
- reduced flavin or flavoprotein:oxygen oxidoreductase
- retinoic acid 4-hydroxylase
- monooxygenase
Pathways
Biological processes and signaling networks where the Cyp2c11 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- proximal tubular toxicity
regulates
- thalidomide
- 5'-hydroxythalidomide
- Cyp2c65/Cyp2c66
- eicosanoid
- 5,6-dihydroxythalidomide
- 5-hydroxythalidomide
- diclofenac
- 5-hydroxy-6-(glutathion-S-yl)diclofenac
- tegafur
- 5-fluorouracil
role in cell
- apoptosis
- proliferation
- quantity
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- intracellular membrane-bounded organelle
- Plasma Membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- microsome