LOC103690326 Gene Summary [Rat]
This gene encodes a seven-pass transmembrane protein that is primarily expressed in dendritic cells. The encoded protein is involved in a range of immunological functions carried out by dendritic cells. This protein plays a role in osteoclastogenesis and myeloid differentiation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
Details
| Type | Protein Coding |
| Official Symbol | LOC103690326 |
| Official Name | dendritic cell-specific transmembrane protein [Source:RGD Symbol;Acc:9418155] |
| Ensembl ID | ENSRNOG00000057189 |
| Bio databases IDs | |
| Aliases | dendritic cell-specific transmembrane protein |
| Synonyms | 4833414I07Rik, Dendritic Cell-Specific Transmembrane, dendrocyte expressed seven transmembrane protein, FIND, hDC-STAMP, mDC-STAMP, TM7SF4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Loc103690326 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DC-STAMP-like protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoporosis
- epithelial thyroid cancer
- mucopolysaccharidosis, MPS-IV-A
- thyroid carcinoma
- osteopetrosis
regulates
role in cell
- fusion
- growth
- formation
- differentiation
- response by
- signaling by
- multinucleation
- osteoclastogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- endoplasmic reticulum membrane
- basolateral membrane
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Loc103690326 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane fusion
- positive regulation of macrophage fusion
- positive regulation of monocyte differentiation
- osteoclast differentiation
- cellular response to transforming growth factor beta stimulus
- osteoclast fusion
- negative regulation of cell growth
- myeloid dendritic cell differentiation
- positive regulation of bone resorption
- cellular response to interleukin-4
- cellular response to tumor necrosis factor
- cellular response to macrophage colony-stimulating factor stimulus
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endosome membrane
- plasma membrane
- endoplasmic reticulum-Golgi intermediate compartment membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding