Ghsr Gene Summary [Rat]
Enables growth hormone secretagogue receptor activity and peptide hormone binding activity. Involved in several processes, including cellular response to insulin-like growth factor stimulus; regulation of digestive system process; and regulation of secretion by cell. Acts upstream of or within negative regulation of insulin secretion. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and synaptic membrane. Used to study middle cerebral artery infarction. Biomarker of isolated growth hormone deficiency; multiple endocrine neoplasia; obstructive sleep apnea; status epilepticus; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in obesity. Orthologous to human GHSR (growth hormone secretagogue receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ghsr |
| Official Name | growth hormone secretagogue receptor [Source:RGD Symbol;Acc:621397] |
| Ensembl ID | ENSRNOG00000024119 |
| Bio databases IDs | |
| Aliases | growth hormone secretagogue receptor |
| Synonyms | C530020I22Rik, GHDP, GHRELIN receptor, GHRP, Ghrp receptor, GH SECRETAGOGUE receptor, growth hormone secretagogue receptor |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ghsr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- hormone binding
- growth hormone-releasing hormone receptor
- Cholecystokinin A receptor, N-terminal
- growth hormone secretagogue receptor
- transmembrane domain
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- growth hormone receptor binding
- identical protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- polypeptide hormone binding
Pathways
Biological processes and signaling networks where the Ghsr gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- anorexia
- weight gain
- obesity
- hepatic steatosis
- non-small cell lung cancer
- epithelial ovarian cancer
- short stature
- non-insulin-dependent diabetes mellitus
- breast carcinoma
role in cell
- proliferation
- expression in
- apoptosis
- phosphorylation in
- differentiation
- activation
- quantity
- growth
- number
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Cytoplasm
- cell surface
- cellular membrane
- synaptic membrane
- neurites
- synapse
- membrane rafts
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ghsr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to food
- regulation of growth hormone secretion
- negative regulation of appetite
- negative regulation of interleukin-1 beta production
- decidualization
- negative regulation of insulin secretion
- adult feeding behavior
- positive regulation of fatty acid metabolic process
- positive regulation of multicellular organism growth
- positive regulation of insulin-like growth factor receptor signaling pathway
- hormone-mediated signaling pathway
- learning or memory
- cellular response to insulin stimulus
- cellular response to thyroid hormone stimulus
- regulation of transmission of nerve impulse
- positive regulation of appetite
- negative regulation of macrophage apoptotic process
- negative regulation of tumor necrosis factor production
- regulation of synapse assembly
- negative regulation of locomotion involved in locomotory behavior
- G-protein coupled receptor signaling pathway
- actin polymerization or depolymerization
- negative regulation of inflammatory response
- spermatogenesis
- regulation of hindgut contraction
- insulin-like growth factor receptor signaling pathway
- response to growth hormone stimulus
- response to hormone stimulus
- negative regulation of interleukin-6 production
- cellular response to lipopolysaccharide
- response to estradiol stimulus
- growth hormone secretion
- response to follicle-stimulating hormone stimulus
- negative regulation of norepinephrine secretion
- response to dexamethasone stimulus
Cellular Component
Where in the cell the gene product is active
- membrane raft
- synaptic membrane
- neuron projection
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- growth hormone secretagogue receptor activity
- peptide hormone binding
- growth hormone-releasing hormone receptor activity