Arhgap4 Gene Summary [Rat]
Enables GTPase activator activity. Involved in negative regulation of axon extension; negative regulation of fibroblast migration; and nervous system development. Located in growth cone and microtubule. Orthologous to human ARHGAP4 (Rho GTPase activating protein 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arhgap4 |
| Official Name | Rho GTPase activating protein 4 [Source:RGD Symbol;Acc:628901] |
| Ensembl ID | ENSRNOG00000058545 |
| Bio databases IDs | |
| Aliases | Rho GTPase activating protein 4 |
| Synonyms | A130009C12RIK, A530015A20Rik, C1, mKIAA0131, p115, p115 RhoGAP, RGC1, RhoGAP4, Rho GTPase activating protein 4, SrGAP4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Arhgap4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- RGS homology domain
- Fes/CIP4, and EFC/F-BAR homology domain
- GTPase activator
- protein binding
- Bin/Amphiphysin/Rvs domain
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
- identical protein binding
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Arhgap4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- acute myeloid leukemia
- organismal death
role in cell
- cell viability
- expression in
- survival
- phosphorylation in
- binding in
- proliferation
- apoptosis
- quantity
- activation in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubules
- cytosol
- nucleoplasm
- growth cone
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Arhgap4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoskeleton organization
- regulation of small GTPase mediated signal transduction
- negative regulation of axon extension
- nervous system development
- negative regulation of fibroblast migration
- Rho protein signal transduction
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- growth cone
- cytoplasm
- cytosol
- nucleoplasm
- microtubule
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity