Limk1 Gene Summary [Rat]
Predicted to enable several functions, including heat shock protein binding activity; ubiquitin ligase inhibitor activity; and ubiquitin protein ligase binding activity. Involved in regulation of modification of postsynaptic actin cytoskeleton. Located in axonal growth cone and perinuclear region of cytoplasm. Is active in glutamatergic synapse. Orthologous to human LIMK1 (LIM domain kinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Limk1 |
| Official Name | LIM domain kinase 1 [Source:RGD Symbol;Acc:62055] |
| Ensembl ID | ENSRNOG00000001470 |
| Bio databases IDs | |
| Aliases | LIM domain kinase 1 |
| Synonyms | KIZ-1, LIM domain kinase 1, LIMK |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Limk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- Domain present in PSD-95, Dlg, and ZO-1/2
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- heat shock protein binding
- enzyme inhibitor activity
- canonical PDZ domain
- enzyme regulator activity
- protein binding
- PDZ domain
- Protein kinase domain
- LIM1 domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- LIM2 domain
- alcohol group acceptor phosphotransferase
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Limk1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- CCR3 Signaling in Eosinophils
- Cdc42 Signaling
- Chemokine Signaling
- Death Receptor Signaling
- Ephrin A Signaling
- Ephrin B Signaling
- Ephrin Receptor Signaling
- Epithelial Adherens Junction Signaling
- Estrogen Receptor Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- IL-8 Signaling
- Natural Killer Cell Signaling
- PAK Signaling
- Rac Signaling
- Reelin Signaling in Neurons
- Regulation of Actin-based Motility by Rho
- RhoA Signaling
- RhoGDI Signaling
- Role of Tissue Factor in Cancer
- Semaphorin Signaling in Neurons
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastatic rectal cancer
- advanced colon cancer
- metastatic colon cancer
- microsatellite instability high colon cancer
- advanced non-small cell lung adenocarcinoma
- advanced rectal cancer
- liver cholangiocarcinoma
- advanced large cell lung carcinoma
- thyroid cancer
role in cell
- phosphorylation in
- degradation in
- proliferation
- replication in
- formation
- formation in
- collapse
- morphology
- migration
- synthesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- axon component
- cell periphery
- perinuclear region
- postsynaptic region
- cellular membrane
- focal adhesions
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- cytosol
- membrane ruffles
- plasma membrane projections
- Golgi membrane
- nuclear speckles
- dendritic spine head
- growth cone
- neurites
- actin foci
- perikaryon
- axonal shafts
- plasma
- lamellipodia
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Limk1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- nervous system development
- positive regulation of axon extension
- Fc-gamma receptor signaling pathway involved in phagocytosis
- Rho protein signal transduction
- protein phosphorylation
- stress fiber assembly
- negative regulation of ubiquitin-protein ligase activity
- positive regulation of stress fiber assembly
- axon extension
- positive regulation of actin filament bundle assembly
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- focal adhesion
- cytoplasm
- nuclear speck
- membrane
- cytosol
- neuron projection
- male germ cell nucleus
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- heat shock protein binding
- ATP binding
- protein binding
- metal ion binding
- protein kinase activity
- protein serine/threonine kinase activity