C3AR1 Gene Summary [Human]
C3a is an anaphylatoxin released during activation of the complement system. The protein encoded by this gene is an orphan G protein-coupled receptor for C3a. Binding of C3a by the encoded receptor activates chemotaxis, granule enzyme release, superoxide anion production, and bacterial opsonization. [provided by RefSeq, May 2016]
Details
| Type | Protein Coding |
| Official Symbol | C3AR1 |
| Official Name | complement C3a receptor 1 [Source:HGNC Symbol;Acc:HGNC:1319] |
| Ensembl ID | ENSG00000171860 |
| Bio databases IDs | |
| Aliases | complement C3a receptor 1 |
| Synonyms | AZ3B, C3AR, complement C3a receptor 1, complement component 3a receptor 1, HNFAG09, Hs.567242 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human C3AR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- complement component C3a receptor
- extracellular loop
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- transmembrane receptor
Pathways
Biological processes and signaling networks where the C3AR1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- epithelial cancer
- cancer
- colon cancer
- osteoarthritis
- peripheral arterial disease
- hypersensitivity reaction type I
- experimental membranous nephropathy
- endotoxemia
- bronchoconstriction
role in cell
- expression in
- accumulation in
- phosphorylation in
- apoptosis
- activation in
- cellular infiltration by
- proliferation
- number
- growth
- chemotaxis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- intracellular space
- cellular membrane
- lysosome
- secretory granule membrane
- specific granule membrane
- apical membrane
- basolateral membrane
- lysosome membrane
- periplasmic membranes
- cytoplasmic vesicles
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human C3AR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- positive regulation of neutrophil chemotaxis
- blood circulation
- phospholipase C-activating G-protein coupled receptor signaling pathway
- complement receptor mediated signaling pathway
- positive regulation of angiogenesis
- elevation of cytosolic calcium ion concentration
- chemotaxis
- inflammatory response
- positive regulation of macrophage chemotaxis
- calcium-mediated signaling
- positive regulation vascular endothelial growth factor production
Cellular Component
Where in the cell the gene product is active
- azurophil granule membrane
- plasma membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- complement component C3a receptor activity
- G-protein coupled receptor activity
- complement component C5a receptor activity