E2f1 Gene Summary [Mouse]
Enables DNA-binding transcription activator activity and transcription cis-regulatory region binding activity. Involved in several processes, including negative regulation of fat cell differentiation; negative regulation of fat cell proliferation; and response to lipopolysaccharide. Acts upstream of or within several processes, including anoikis; lens fiber cell apoptotic process; and quinolinate biosynthetic process. Located in chromatin and cytoplasm. Part of transcription regulator complex. Is active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and lung. Used to study Sjogren's syndrome and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in lung carcinoma (multiple); osteosarcoma; and pancreatic adenocarcinoma (multiple). Orthologous to human E2F1 (E2F transcription factor 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | E2f1 |
| Official Name | E2F transcription factor 1 [Source:MGI Symbol;Acc:MGI:101941] |
| Ensembl ID | ENSMUSG00000027490 |
| Bio databases IDs | |
| Aliases | E2F transcription factor 1 |
| Synonyms | E2f, E2F transcription factor 1, mKIAA4009, RBAP1, RBBP3, RBP3, Tg(Wnt1-cre)2Sor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse E2f1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription activation domain
- transcription factor binding
- leucine zipper domain
- retinoblastoma protein binding domain
- pocket domain
- DP1 binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- Sp1 binding domain
- marked box
- pRb binding domain
- activation domain
- dimerization domain
- protein kinase binding
- DNA binding domain
- nucleic acid binding
- nuclear localization sequence
- central domain
- protein binding
- Dimerization domain of E2F transcription factors
- sequence-specific DNA binding
- Mdm2 protein binding domain
- cyclin-dependent kinase binding domain
- DNA binding
- cyclin-CDK binding domain
- cyclin A-binding domain
- double-stranded DNA binding
- ATM phosphorylation site
- heterodimerization domain
- E2F/DP family winged-helix DNA-binding domain
- cyclin-binding domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the E2f1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Aryl Hydrocarbon Receptor Signaling
- Autophagy
- BER pathway
- Bladder Cancer Signaling
- Cell Cycle Regulation by BTG Family Proteins
- Cyclins and Cell Cycle Regulation
- DNA damage-induced 14-3-3σ Signaling
- DNA Methylation and Transcriptional Repression Signaling
- Estrogen-mediated S-phase Entry
- Glioma Signaling
- Hereditary Breast Cancer Signaling
- Melanoma Signaling
- Molecular Mechanisms of Cancer
- Non-Small Cell Lung Cancer Signaling
- p53 Signaling
- Pancreatic Adenocarcinoma Signaling
- Prostate Cancer Signaling
- Role of BRCA1 in DNA Damage Response
- Role of CHK Proteins in Cell Cycle Checkpoint Control
- Role of p14/p19ARF in Tumor Suppression
- Small Cell Lung Cancer Signaling
- Telomerase Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- benign neoplasia
- acute myeloid leukemia
- ovarian neoplasia
- neoplasia
- immunodeficiency
- diabetes mellitus
- liver cancer
- gastric cancer
- cancer
role in cell
- survival
- phosphorylation in
- shortening
- apoptosis
- G1 phase
- growth
- cell death
- outgrowth
- autophagy by
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- intranuclear region
- centrosome
- Mitochondria
- nuclear foci
- chromosome
- nucleoplasm
- nucleoli
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse E2f1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription, DNA-dependent
- negative regulation of fat cell differentiation
- anoikis
- regulation of transcription, DNA-dependent
- DNA damage response, signal transduction resulting in induction of apoptosis
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- DNA damage checkpoint
- negative regulation of DNA binding
- forebrain development
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- positive regulation of gene expression
- signal transduction by p53 class mediator resulting in induction of apoptosis
- positive regulation of fibroblast proliferation
- mRNA stabilization
- positive regulation of apoptotic process
- regulation of G1/S transition of mitotic cell cycle
- cellular response to xenobiotic stimulus
- negative regulation of fat cell proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
- Rb-E2F complex
- centrosome
- cytoplasm
- macromolecular complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- protein dimerization activity
- sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- binding, bridging