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Melanoma Signaling

Melanoma progressses through 5 phenotypically distinct stages: benign nevus, dysplastic nevus, radial-growth phase, vertical-growth phase, culminating in metastatic melanoma. Environmental and genetic factors play a role in the disease progression. Oncogenic mutations in B-Raf and N-Ras activate the Raf-MEK-ERK pathway while mutations in N-Ras and PTEN activate the PI3K-AKT pathway leading to uncontrolled proliferation and cell survival. These mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression....

Melanoma Signaling

Pathway Summary

Melanoma progressses through 5 phenotypically distinct stages: benign nevus, dysplastic nevus, radial-growth phase, vertical-growth phase, culminating in metastatic melanoma. Environmental and genetic factors play a role in the disease progression. Oncogenic mutations in B-Raf and N-Ras activate the Raf-MEK-ERK pathway while mutations in N-Ras and PTEN activate the PI3K-AKT pathway leading to uncontrolled proliferation and cell survival. These mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression.Melanoma development is also associated with genetic alterations to genes in tumor supressor pathways. Genes that are mutated include p16INK4a and CDK4 from the retiblastoma pathway and p14/ARF and p53 from the p53 pathway.Microphthalmia-associated transcription factor (MITF) acts as a master regulator of melanocyte development, function and survival by modulating differentiation and cell-cycle progression genes. MITF is an amplified oncogene in a fraction of human melanomas.

Melanoma Signaling Genes list

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GeneGlobe ID: UPHS-058Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human PI3K-AKT Signaling Pathway
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GeneGlobe ID: UPHS-061Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human MAP Kinase Signaling Pathway
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GeneGlobe ID: SBHS-033Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
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GeneGlobe ID: PAHS-058Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human PI3K-AKT Signaling Pathway
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GeneGlobe ID: PAHS-061Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
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GeneGlobe ID: PAHS-033Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Cancer PathwayFinder™
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