Timp3 Gene Summary [Mouse]
Predicted to enable metalloendopeptidase inhibitor activity and zinc ion binding activity. Involved in negative regulation of metalloendopeptidase activity. Located in basement membrane. Is expressed in several structures, including alimentary system; central nervous system; eye posterior segment; genitourinary system; and musculoskeletal system. Used to study Sorsby's fundus dystrophy and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in Sorsby's fundus dystrophy; breast carcinoma; and urinary bladder cancer. Orthologous to human TIMP3 (TIMP metallopeptidase inhibitor 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Timp3 |
| Official Name | tissue inhibitor of metalloproteinase 3 [Source:MGI Symbol;Acc:MGI:98754] |
| Ensembl ID | ENSMUSG00000020044 |
| Bio databases IDs | |
| Aliases | tissue inhibitor of metalloproteinase 3 |
| Synonyms | HSMRK222, K222, K222TA2, SFD, TIMP metallopeptidase inhibitor 3, tissue inhibitor of metalloproteinase 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Timp3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NTR_like
- zinc ion binding
- protein binding
- metalloendopeptidase inhibitor
- Tissue inhibitor of metalloproteinase
Pathways
Biological processes and signaling networks where the Timp3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- squamous cell cancer of the oral cavity
- asthma
- prostate cancer
- breast cancer
- colon cancer
- lung adenocarcinoma
- pancreatic epithelial cancer
- heart failure
phenotypes
- abnormal retina morphology
- abnormal retinal blood vessel morphology
- increased startle reflex
- abdominal aorta aneurysm
- abnormal Bruch membrane morphology
- abnormal abdominal aorta morphology
- abnormal aorta morphology
- abnormal aorta wall morphology
- abnormal apoptosis
- abnormal artery morphology
- abnormal blood vessel elastic tissue morphology
- abnormal blood vessel physiology
- abnormal branching involved in terminal bronchiole morphogenesis
- abnormal bronchiole morphology
- abnormal cardiac muscle relaxation
- abnormal choroid vasculature morphology
- abnormal heart left ventricle morphology
- abnormal heart morphology
- abnormal involution of the mammary gland
- abnormal kidney morphology
- abnormal lactation
- abnormal learning/memory/conditioning
- abnormal liver lobule morphology
- abnormal pulmonary alveolus morphology
- abnormal pulmonary alveolus wall morphology
- abnormal respiratory system physiology
- abnormal retinal pigment epithelium morphology
- abnormal spatial learning
- abnormal systemic arterial blood pressure
- abnormal vascular branching morphogenesis
- aortitis
- cardiac fibrosis
- cardiac hypertrophy
- congestive heart failure
- decreased body weight
- decreased cardiac muscle contractility
- decreased circulating glucose level
- decreased lean body mass
- decreased left ventricle developed pressure
- decreased left ventricle systolic pressure
- decreased liver regeneration
- decreased susceptibility to induced hypothermia
- decreased systemic arterial blood pressure
- decreased vasodilation
- decreased ventricle muscle contractility
- dilated cardiomyopathy
- dilated heart left ventricle
- dilated terminal bronchiole tubes
- enlarged kidney
- hepatic necrosis
- hunched posture
- hydronephrosis
- impaired lung alveolus development
- increased body temperature
- increased carbon dioxide production
- increased hepatocyte apoptosis
- increased oxygen consumption
- increased response of heart to induced stress
- increased sensitivity to induced morbidity/mortality
- increased susceptibility to injury
- increased tumor necrosis factor secretion
- lethargy
- liver inflammation
- overexpanded pulmonary alveoli
- premature death
- pulmonary edema
- respiratory distress
- ruffled hair
role in cell
- growth
- quantity
- morphology
- cell death
- expression in
- degradation in
- phosphorylation in
- cellular infiltration by
- proliferation
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- secretory granule lumen
- cell surface
- basal compartment
- extracellular matrix
- perikaryon
- dendrites
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Timp3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cytokine stimulus
- negative regulation of membrane protein ectodomain proteolysis
- negative regulation of endopeptidase activity
- response to hormone stimulus
- visual perception
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- basement membrane
- platelet dense granule lumen
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- protease binding
- metalloendopeptidase inhibitor activity