Fbxo5 Gene Summary [Mouse]
Predicted to enable anaphase-promoting complex binding activity; protein kinase binding activity; and ubiquitin ligase inhibitor activity. Involved in regulation of mitotic cell cycle. Acts upstream of or within several processes, including microtubule cytoskeleton organization; negative regulation of meiotic nuclear division; and oocyte maturation. Located in cytoplasm and meiotic spindle. Is expressed in several structures, including brain; early conceptus; gonad; metanephros; and spleen. Orthologous to human FBXO5 (F-box protein 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fbxo5 |
| Official Name | F-box protein 5 [Source:MGI Symbol;Acc:MGI:1914391] |
| Ensembl ID | ENSMUSG00000019773 |
| Bio databases IDs | |
| Aliases | F-box protein 5 |
| Synonyms | 2510044I10Rik, EMI1, F-box protein 5, FBX5, Fbxo31 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fbxo5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain
- IBR domain, a half RING-finger domain
- binding protein
- protein kinase binding
- F-box domain superfamily
- enzyme inhibitor activity
- BRcat_Rcat_RBR
- enzyme
- protein binding
- enzyme regulator activity
Pathways
Biological processes and signaling networks where the Fbxo5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon adenocarcinoma
- colon epithelial cancer
- neoplasia
- mammary neoplasm
- breast carcinoma
- colon neoplasm
- colorectal neoplasia
role in cell
- expression in
- proliferation
- apoptosis
- cell viability
- formation
- accumulation in
- differentiation
- G2/M phase
- cell survival
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- spindle apparatus
- Cytoplasm
- cytosol
- nucleoplasm
- mitotic spindle
- meiotic spindles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fbxo5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of mitosis
- positive regulation of cell proliferation
- negative regulation of mitotic metaphase/anaphase transition
- regulation of DNA replication
- microtubule polymerization
- spindle assembly involved in female meiosis I
- response to DNA damage stimulus
- positive regulation of osteoblast differentiation
- negative regulation of meiosis
- regulation of mitotic cell cycle
- cell division
- negative regulation of ubiquitin-protein ligase activity
- oocyte maturation
- vesicle organization
- positive regulation of biomineral tissue development
- negative regulation of DNA endoreduplication
- negative regulation of cellular senescence
- protein ubiquitination
- positive regulation of G2/M transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- spindle
- cytosol
- meiotic spindle
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- metal ion binding
- anaphase-promoting complex binding