Zeb1 Gene Summary [Mouse]
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding activity; and chromatin binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of neuron differentiation. Acts upstream of or within several processes, including embryonic organ morphogenesis; negative regulation of keratinocyte proliferation; and regulation of T cell differentiation in thymus. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study HTLV-1-associated myelopathy/tropical spastic paraparesis. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy and posterior polymorphous corneal dystrophy 3. Orthologous to human ZEB1 (zinc finger E-box binding homeobox 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Zeb1 |
| Official Name | zinc finger E-box binding homeobox 1 [Source:MGI Symbol;Acc:MGI:1344313] |
| Ensembl ID | ENSMUSG00000024238 |
| Bio databases IDs | |
| Aliases | zinc finger E-box binding homeobox 1 |
| Synonyms | 3110032K11Rik, AREB6, BZP, DELTAEF1, [delta]EF1, FECD6, LOC100996668, MEB1, Nil2, NIL2A, PPCD3, Tcf18, TCF-8, TCP8, TF8, TRANSCRIPTION FACTOR 8, Tw, ZEB, ZFHEP, Zfhep2, ZFHX1A, Zfx1a, Zfx1ha, zinc finger E-box binding homeobox 1, [δ]EF1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zeb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- transcription regulator
- DNA binding domain
- nucleic acid binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- C2H2-type zinc finger
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- zinc finger
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- transcription repression domain
- zinc ion binding
- double-stranded DNA binding
- Zinc-finger double domain
- zinc finger domain
- homeodomain
- transcription factor activity
Pathways
Biological processes and signaling networks where the Zeb1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- bleeding
- neoplasia
- lymphomagenesis
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
- lymphatic neoplasia
- breast cancer
- androgenic alopecia
phenotypes
- Meckel's cartilage hyperplasia
- abnormal B cell differentiation
- abnormal T cell differentiation
- abnormal T cell subpopulation ratio
- abnormal abdominal fat pad morphology
- abnormal basisphenoid bone morphology
- abnormal circulating hormone level
- abnormal circulating lipid level
- abnormal class switch recombination
- abnormal cochlea morphology
- abnormal cornea morphology
- abnormal corneal endothelium morphology
- abnormal corneal stroma morphology
- abnormal cranial blood vasculature morphology
- abnormal craniofacial bone morphology
- abnormal cribriform plate morphology
- abnormal crista ampullaris morphology
- abnormal crista ampullaris neuroepithelium morphology
- abnormal eating behavior
- abnormal elbow joint morphology
- abnormal ethmoid bone morphology
- abnormal hindlimb morphology
- abnormal hip joint morphology
- abnormal inguinal fat pad morphology
- abnormal inner ear canal morphology
- abnormal inner ear morphology
- abnormal iridocorneal angle
- abnormal jaw morphology
- abnormal lateral semicircular canal morphology
- abnormal mandibular angle morphology
- abnormal maxillary shelf morphology
- abnormal memory B cell physiology
- abnormal nasal cavity morphology
- abnormal nasal septum morphology
- abnormal navicular morphology
- abnormal olfactory bulb glomerular layer morphology
- abnormal olfactory bulb layer morphology
- abnormal olfactory bulb mitral cell layer morphology
- abnormal olfactory bulb morphology
- abnormal olfactory epithelium morphology
- abnormal olfactory nerve morphology
- abnormal olfactory sensory neuron morphology
- abnormal otolith morphology
- abnormal parental behavior
- abnormal phalanx morphology
- abnormal posterior semicircular canal morphology
- abnormal postural reflex
- abnormal premaxilla morphology
- abnormal pterygoid bone morphology
- abnormal rib morphology
- abnormal scala media morphology
- abnormal secondary palate development
- abnormal semicircular canal ampulla morphology
- abnormal semicircular canal morphology
- abnormal sensory neuron innervation pattern
- abnormal serous gland morphology
- abnormal sternebra morphology
- abnormal sternum morphology
- abnormal suckling behavior
- abnormal superior semicircular canal morphology
- abnormal tarsal bone morphology
- abnormal thymus development
- abnormal turbinate morphology
- abnormal vascular smooth muscle physiology
- abnormal vascular wound healing
- abnormal xiphoid process morphology
- absent lateral semicircular canal
- absent marginal zone B cells
- absent otoliths
- anterior iris synechia
- ascites
- bidirectional circling
- bowed radius
- bowed tibia
- brachyphalangia
- circling
- cleft palate
- cleft secondary palate
- cleft upper lip
- corneal abrasion
- corneal epithelium hypoplasia
- curly tail
- cyanosis
- cyclopia
- decreased B cell proliferation
- decreased B-1 B cell number
- decreased B-1a cell number
- decreased B-1b cell number
- decreased CD8-positive alpha-beta T cell number
- decreased IgG level
- decreased IgG1 level
- decreased IgM level
- decreased NK cell number
- decreased T cell number
- decreased body size
- decreased cochlear coiling
- decreased double-positive T cell number
- decreased germinal center B cell number
- decreased lateral semicircular canal size
- decreased length of long bones
- decreased leukocyte cell number
- decreased lymphocyte cell number
- decreased neutrophil cell number
- decreased otolith number
- decreased oxygen consumption
- decreased posterior semicircular canal size
- decreased splenocyte number
- decreased thymocyte number
- delayed endochondral bone ossification
- dilated endolymphatic duct
- diluted coat color
- distended abdomen
- edema
- enlarged otoliths
- exencephaly
- female infertility
- fetal growth retardation
- fused carpal bones
- fused metatarsal bones
- head bobbing
- head shaking
- hemorrhage
- hydrops fetalis
- hyperactivity
- hypoactivity
- impaired glucose tolerance
- impaired humoral immune response
- increased T cell derived lymphoma incidence
- increased aggression towards males
- increased body weight
- increased circulating adiponectin level
- increased circulating corticosterone level
- increased circulating free fatty acid level
- increased circulating insulin level
- increased circulating leptin level
- increased circulating triglyceride level
- increased food intake
- increased or absent threshold for auditory brainstem response
- increased percent body fat/body weight
- increased single-positive T cell number
- increased susceptibility to age related obesity
- increased thymocyte number
- increased total body fat amount
- infertility
- insulin resistance
- intervertebral disk hypoplasia
- lymph node hypoplasia
- mandible hypoplasia
- mandibular condyloid process hypoplasia
- mandibular coronoid process hypoplasia
- meteorism
- midline facial cleft
- neonatal lethality complete penetrance
- obese
- open neural tube
- palatal shelves fail to meet at midline
- palate bone hypoplasia
- patellar dislocation
- perinatal lethality complete penetrance
- postnatal growth retardation
- postnatal lethality incomplete penetrance
- premature death
- reduced male fertility
- respiratory distress
- respiratory failure
- rib fusion
- short limbs
- short mandible
- short maxilla
- short premaxilla
- short scapula
- short sternum
- small spleen
- small thymus
- sparse hair
- syndactyly
- thymus hypoplasia
- transmission ratio distortion
- turbinate hypoplasia
role in cell
- quantity
- number
- formation
- formation in
- apoptosis
- survival
- expression in
- phosphorylation in
- glycolysis in
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zeb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- anatomical structure development
- regulation of smooth muscle cell differentiation
- positive regulation of neuron differentiation
- regulation of T cell differentiation in thymus
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of endothelial cell differentiation
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of keratinocyte proliferation
- cellular response to amino acid stimulus
- forebrain development
- negative regulation of transcription, DNA-dependent
- keratinocyte proliferation
- cochlea morphogenesis
- pattern specification process
- embryonic skeletal system morphogenesis
- regulation of transcription from RNA polymerase II promoter
- cellular response to transforming growth factor beta stimulus
- semicircular canal morphogenesis
- embryonic camera-type eye morphogenesis
- cell differentiation
- response to activity
- regulation of transforming growth factor beta receptor signaling pathway
- regulation of mesenchymal cell proliferation
- response to nutrient levels
- cartilage development
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- chromatin binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- E-box binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity