Lif Gene Summary [Mouse]
Enables cytokine activity and growth factor activity. Acts upstream of or within several processes, including cell differentiation involved in embryonic placenta development; lung development; and positive regulation of macromolecule biosynthetic process. Located in extracellular space. Is expressed in several structures, including alimentary system; early conceptus; hemolymphoid system; nervous system; and reproductive system. Orthologous to human LIF (LIF interleukin 6 family cytokine). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lif |
| Official Name | leukemia inhibitory factor [Source:MGI Symbol;Acc:MGI:96787] |
| Ensembl ID | ENSMUSG00000034394 |
| Bio databases IDs | |
| Aliases | leukemia inhibitory factor |
| Synonyms | CDF, cholinergic differentiation factor, DIA, HILDA, leukaemia inhibitory factor, leukemia inhibitory factor, LIF interleukin 6 family cytokine, LIF, interleukin 6 family cytokine, MLPLI |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lif often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- leukemia inhibitory factor receptor binding
- receptor binding domain
- LIF / OSM family
- AB loop
- CD loop
- protein binding
- receptor binding
- cytokine
- growth factor
- D helix
Pathways
Biological processes and signaling networks where the Lif gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- ERK5 Signaling
- Erythropoietin Signaling
- Hematopoiesis from Pluripotent Stem Cells
- Hepatic Cholestasis
- HMGB1 Signaling
- Human Embryonic Stem Cell Pluripotency
- IL-17 Signaling
- Mouse Embryonic Stem Cell Pluripotency
- RAR Activation
- Role of JAK family kinases in IL-6-type Cytokine Signaling
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of NFAT in Cardiac Hypertrophy
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Transcriptional Regulatory Network in Embryonic Stem Cells
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- epithelial neoplasia
- cancer
- hypogonadism
- cachexia
- diarrhea
- endometriosis
- systemic lupus erythematosus
- mature T-cell neoplasia
phenotypes
- abnormal CNS glial cell morphology
- abnormal astrocyte morphology
- abnormal blood vessel morphology
- abnormal brain vasculature morphology
- abnormal capillary morphology
- abnormal circulating serum amyloid protein level
- abnormal embryo apposition
- abnormal embryo attachment
- abnormal glial cell morphology
- abnormal hepatocyte morphology
- abnormal induced retinal neovascularization
- abnormal involution of the mammary gland
- abnormal macrophage morphology
- abnormal mammary gland alveolus morphology
- abnormal mammary gland duct morphology
- abnormal mammary gland growth during pregnancy
- abnormal mammary gland physiology
- abnormal osteoclast differentiation
- abnormal osteoclast morphology
- abnormal osteoclast physiology
- abnormal pilomotor reflex
- abnormal retinal vasculature morphology
- abnormal skeleton morphology
- abnormal uterine receptivity
- abnormal uterus morphology
- decreased T cell proliferation
- decreased body size
- decreased body weight
- decreased bone volume
- decreased circulating adrenocorticotropin level
- decreased circulating triglyceride level
- decreased common myeloid progenitor cell number
- decreased erythroid progenitor cell number
- decreased hematopoietic stem cell number
- decreased interleukin-10 secretion
- decreased leukocyte cell number
- decreased motor neuron number
- decreased susceptibility to injury
- diarrhea
- failure of embryo implantation
- female infertility
- hepatic necrosis
- hypoxia
- increased acute inflammation
- increased bone resorption
- increased circulating alanine transaminase level
- increased circulating aspartate transaminase level
- increased circulating insulin-like growth factor I level
- increased circulating interleukin-1 beta level
- increased circulating interleukin-6 level
- increased circulating leptin level
- increased circulating tumor necrosis factor level
- increased eosinophil cell number
- increased osteoclast cell number
- increased susceptibility to bacterial infection induced morbidity/mortality
- increased susceptibility to endotoxin shock
- increased susceptibility to weight loss
- increased uterine NK cell number
- increased vascular endothelial cell proliferation
- liver hemorrhage
- liver vascular congestion
- postnatal growth retardation
- postnatal lethality incomplete penetrance
- thrombocytopenia
- tremors
role in cell
- phosphorylation in
- activation in
- accumulation in
- apoptosis
- expression in
- proliferation
- growth
- cell viability
- cell death
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- Nucleus
- Plasma Membrane
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lif gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lung lobe morphogenesis
- negative regulation of cell proliferation
- positive regulation of cell proliferation
- positive regulation of peptidyl-serine phosphorylation of STAT protein
- lung vasculature development
- decidualization
- positive regulation of astrocyte differentiation
- positive regulation of tyrosine phosphorylation of STAT protein
- positive regulation of transcription from RNA polymerase II promoter
- fibroblast proliferation
- lung alveolus development
- response to hypoxia
- immune response
- stem cell differentiation
- regulation of cell differentiation
- positive regulation of macrophage differentiation
- leukemia inhibitory factor signaling pathway
- trophoblast giant cell differentiation
- positive regulation of fibroblast proliferation
- somatic stem cell maintenance
- positive regulation of cell adhesion mediated by integrin
- regulation of metanephric nephron tubule epithelial cell differentiation
- positive regulation of peptidyl-tyrosine phosphorylation
- macrophage differentiation
- positive regulation of peptidyl-serine phosphorylation
- positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
- cell morphogenesis
- positive regulation of MAPK cascade
- muscle organ morphogenesis
- neuron development
- negative regulation of meiosis
- negative regulation of hormone secretion
- embryo implantation
- blood vessel remodeling
- positive regulation of gene expression
- negative regulation of ERK1 and ERK2 cascade
- gene expression
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytosol
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- cytokine activity
- receptor binding
- leukemia inhibitory factor receptor binding