Foxc2 Gene Summary [Mouse]
Enables several functions, including DNA-binding transcription activator activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and promoter-specific chromatin binding activity. Involved in several processes, including positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of vascular wound healing; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including cell surface receptor signaling pathway; circulatory system development; and kidney development. Predicted to be located in nuclear body. Is expressed in several structures, including cardiovascular system; central nervous system; embryo mesenchyme; limb long bone; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including lymphedema; lymphedema-distichiasis syndrome; obesity; ptosis; and type 2 diabetes mellitus. Orthologous to human FOXC2 (forkhead box C2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Foxc2 |
| Official Name | forkhead box C2 [Source:MGI Symbol;Acc:MGI:1347481] |
| Ensembl ID | ENSMUSG00000046714 |
| Bio databases IDs | |
| Aliases | forkhead box C2 |
| Synonyms | Fkh14, FKHL14, forkhead box C2, Hfhbf3, LD, MFH-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Foxc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- FH_FOX
- DNA binding domain
- nucleic acid binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- identical protein binding
- DNA binding
- Forkhead domain
- FORKHEAD
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- transcription factor activity
Pathways
Biological processes and signaling networks where the Foxc2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- neoplasia
- metastasis
- lymphedema distichiasis
- obesity
- idiopathic hydrops fetalis
- breast carcinoma
- clear cell sarcoma of the kidney
phenotypes
- abnormal Meckel's cartilage morphology
- abnormal alisphenoid bone morphology
- abnormal aortic arch morphology
- abnormal basisphenoid bone morphology
- abnormal blood vessel morphology
- abnormal bone ossification
- abnormal canal of Schlemm morphology
- abnormal cartilage morphology
- abnormal craniofacial bone morphology
- abnormal eye morphology
- abnormal fourth pharyngeal arch artery morphology
- abnormal glomerular mesangium morphology
- abnormal gonial bone morphology
- abnormal iridocorneal angle
- abnormal iris morphology
- abnormal iris pigment epithelium
- abnormal lymph circulation
- abnormal malleus morphology
- abnormal mesangial cell morphology
- abnormal middle ear ossicle morphology
- abnormal multipotent stem cell morphology
- abnormal orbit morphology
- abnormal otic vesicle development
- abnormal palatine bone horizontal plate morphology
- abnormal podocyte morphology
- abnormal presphenoid bone morphology
- abnormal pterygoid process morphology
- abnormal renal glomerulus basement membrane morphology
- abnormal renal glomerulus morphology
- abnormal somite shape
- abnormal sphenoid bone morphology
- abnormal supraoccipital bone morphology
- abnormal third pharyngeal arch artery morphology
- abnormal thoracic duct morphology
- abnormal trabecular meshwork morphology
- abnormal vertebral arch morphology
- abnormal vertebral body morphology
- absent cartilage
- absent glomerular endothelium fenestra
- absent incus
- absent palatine bone
- absent palatine bone horizontal plate
- absent podocyte foot process
- absent podocyte slit diaphragm
- absent presphenoid bone
- absent soft palate
- absent stapes
- absent supraoccipital bone
- aortic arch coarctation
- atelectasis
- blepharoptosis
- cataract
- cleft palate
- cleft secondary palate
- corneal abrasion
- decreased glomerular capillary number
- decreased renal glomerulus number
- decreased rib number
- decreased tympanic ring size
- dilated glomerular capillary
- embryonic lethality during organogenesis incomplete penetrance
- enlarged lymph nodes
- extremity edema
- eye opacity
- glomerulus hemorrhage
- gonial bone hypoplasia
- increased brown adipose tissue amount
- increased lymph node number
- interrupted aortic arch
- intracranial hemorrhage
- iris stroma hypoplasia
- kinked neural tube
- lymphangiectasis
- lymphatic vessel hyperplasia
- lymphedema
- malleus hypoplasia
- no abnormal phenotype detected
- ocular distichiasis
- perinatal lethality complete penetrance
- periorbital edema
- rib fusion
- short vertebral body
- small Meckel's cartilage
- small basioccipital bone
- small exoccipital bone
- small interparietal bone
- small kidney
- small mandible
- small pterygoid bone
- small temporal bone squamous part
- small vertebral body
- spina bifida occulta
- spinal hemorrhage
- thin myocardium
- ventricular septal defect
role in cell
- expression in
- formation
- quantity
- proliferation
- activation in
- phosphorylation in
- growth
- migration
- transmembrane potential
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nucleoplasm
- nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Foxc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ventricular cardiac muscle tissue morphogenesis
- insulin receptor signaling pathway
- mesoderm development
- anatomical structure morphogenesis
- apoptotic process involved in outflow tract morphogenesis
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of cell migration involved in sprouting angiogenesis
- negative regulation of transcription from RNA polymerase II promoter
- heart development
- ossification
- positive regulation of transcription, DNA-dependent
- patterning of blood vessels
- camera-type eye development
- paraxial mesodermal cell fate commitment
- glomerular mesangial cell development
- lymphangiogenesis
- positive regulation of cell adhesion mediated by integrin
- positive regulation of endothelial cell migration
- positive regulation of vascular wound healing
- neural crest cell development
- artery morphogenesis
- regulation of organ growth
- embryonic heart tube development
- response to hormone stimulus
- cardiac muscle cell proliferation
- embryonic viscerocranium morphogenesis
- regulation of transcription from RNA polymerase II promoter
- glomerular endothelium development
- vascular endothelial growth factor receptor signaling pathway
- blood vessel remodeling
- Notch signaling pathway
- metanephros development
- somitogenesis
- ureteric bud development
- glomerular visceral epithelial cell differentiation
- cell differentiation
- collagen fibril organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- identical protein binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity