GATAD2A Gene Summary
Enables protein-macromolecule adaptor activity. Involved in negative regulation of transcription, DNA-templated. Located in nucleoplasm. Part of NuRD complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | GATAD2A |
| Official Name | GATA zinc finger domain containing 2A [Source:HGNC Symbol;Acc:HGNC:29989] |
| Ensembl ID | ENSG00000167491 |
| Bio databases IDs | |
| Aliases | GATA zinc finger domain containing 2A, p66 alpha |
| Synonyms | 1110066C11Rik,BC031407,C80248,GATA zinc finger domain containing 2A,p66alpha,RGD1310596 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Coiled-coil and interaction region of P66A and P66B with MBD2
- protein binding activity, bridging
- protein binding
- ZnF_GATA
Pathways
Biological processes and signaling networks where the GATAD2A gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- neoplasia
- epithelial cancer
- non-insulin-dependent diabetes mellitus
- prostate cancer
- prostatic carcinoma
- refractive error
- dyslexia
- gastroesophageal reflux
- ovarian carcinoma
role in cell
- production in
- apoptosis
- expression in
- accumulation
- K63 polyubiquitination in
- transcription in
- remodeling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the GATAD2A gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of cell fate specification
- chromatin remodeling
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- regulation of stem cell differentiation
cellular COMPONENT
Where in the cell the gene product is active
- nucleus
- nuclear speck
- NuRD complex
- nucleoplasm
molecular FUNCTION
What the gene product does at the molecular level
- protein binding
- metal ion binding
- sequence-specific DNA binding
- protein binding, bridging