NFYB Gene Summary
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | NFYB |
| Official Name | nuclear transcription factor Y subunit beta [Source:HGNC Symbol;Acc:HGNC:7805] |
| Ensembl ID | ENSG00000120837 |
| Bio databases IDs | |
| Aliases | nuclear transcription factor Y subunit beta |
| Synonyms | CBF-A,CBF-B,HAP3,Nfya,nuclear transcription factor-Y beta,nuclear transcription factor Y subunit beta,nuclear transcription factor Y subunit β,nuclear transcription factor-Y β |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone-fold domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- transcription factor binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- histone fold domain (HFD) superfamily
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- binding protein
- double-stranded DNA binding
- transcription factor activity
Pathways
Biological processes and signaling networks where the NFYB gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dysferlinopathy
- early onset gastric cancer
- organismal death
role in cell
- inhibition in
- expression in
- production in
- differentiation
- epithelial-mesenchymal transition
- transactivation in
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the NFYB gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
cellular COMPONENT
Where in the cell the gene product is active
- CCAAT-binding factor complex
- nucleus
- protein-DNA complex
- chromatin
- nucleoplasm
molecular FUNCTION
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- protein heterodimerization activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity