POLE4 Gene Summary [Human]
POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]
Details
| Type | Protein Coding |
| Official Symbol | POLE4 |
| Official Name | DNA polymerase epsilon 4, accessory subunit [Source:HGNC Symbol;Acc:HGNC:18755] |
| Ensembl ID | ENSG00000115350 |
| Bio databases IDs | |
| Aliases | DNA polymerase epsilon 4, accessory subunit |
| Synonyms | 2400007P05Rik, 5830430F06RIK, DNA polymerase epsilon 4, accessory subunit, DNA polymerase ε 4, accessory subunit, p12, polymerase (DNA-directed), epsilon 4 (p12 subunit), polymerase (DNA-directed), ε 4 (p12 subunit), YHHQ1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human POLE4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone fold domain (HFD) superfamily
- DNA-directed DNA polymerase
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the POLE4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- diffuse large B-cell lymphoma
- cutaneous mastocytosis
- chronic lymphocytic leukemia
- lymphocytic leukemia
- intermediate-risk acute myeloid leukemia
- secondary progressive multiple sclerosis
- RUNX1-RUNX1T1 positive acute myeloid leukemia
- indolent systemic mastocytosis
- mantle cell lymphoma
role in cell
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human POLE4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA-dependent DNA replication
- DNA biosynthetic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- epsilon DNA polymerase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- DNA-directed DNA polymerase activity
- protein binding
- protein heterodimerization activity