Arntl Gene Summary [Mouse]
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with Clock. This heterodimer binds E-box enhancer elements upstream of Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2) genes and activates transcription of these genes. Per and Cry proteins heterodimerize and repress their own transcription by interacting in a feedback loop with Clock/Arntl complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2014]
Details
| Type | Protein Coding |
| Official Symbol | Arntl |
| Official Name | aryl hydrocarbon receptor nuclear translocator-like [Source:MGI Symbol;Acc:MGI:1096381] |
| Ensembl ID | ENSMUSG00000055116 |
| Bio databases IDs | |
| Aliases | aryl hydrocarbon receptor nuclear translocator-like |
| Synonyms | Arnt3, ARNTL, ARNTL1, basic helix-loop-helix ARNT like 1, bHLHe5, BMAL1b, bmal1b', BMAL1c, JAP3, MOP3, PASD3, TIC |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arntl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- disorder 1 domain of mammalian ARNTL
- transcription regulator
- nucleic acid binding
- PAS domain S-box
- heat shock protein binding
- PAS
- basic Helix Loop Helix (bHLH) domain superfamily
- transcription cofactor
- transcription factor binding
- protein binding
- basic helix loop helix/Per Arnt Sim domain
- sequence-specific DNA binding
- PAS fold
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- aryl hydrocarbon receptor binding
- PAS domain
- double-stranded DNA binding
- helix loop helix domain
- PAS A-subdomain
- Helix-loop-helix DNA-binding domain
- transcription factor activity
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Arntl gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- schizophrenia
- neurotic disorder
- epithelial cancer
- epithelial neoplasia
- cancer
- liver neoplasia
- neoplasia
- non-insulin-dependent diabetes mellitus
- obesity
phenotypes
- abnormal B cell differentiation
- abnormal T cell subpopulation ratio
- abnormal blood coagulation
- abnormal circadian behavior
- abnormal circadian behavior phase
- abnormal circadian regulation of heart rate
- abnormal circadian regulation of systemic arterial blood pressure
- abnormal circadian sleep/wake cycle
- abnormal circulating adrenaline level
- abnormal circulating protein level
- abnormal cornea morphology
- abnormal corneal stroma morphology
- abnormal costal cartilage morphology
- abnormal eye electrophysiology
- abnormal gait
- abnormal gluconeogenesis
- abnormal glucose homeostasis
- abnormal hair cycle
- abnormal hair cycle anagen phase
- abnormal hair follicle matrix region morphology
- abnormal knee joint morphology
- abnormal lens fiber morphology
- abnormal lens morphology
- abnormal ligament morphology
- abnormal lipid homeostasis
- abnormal lipid level
- abnormal locomotor activation
- abnormal locomotor circadian rhythm
- abnormal metabolism
- abnormal nitric oxide homeostasis
- abnormal posture
- abnormal response to injury
- abnormal rib morphology
- abnormal sleep pattern
- abnormal tail movements
- abnormal thoracic cage morphology
- abnormal thrombosis
- abnormal vascular smooth muscle physiology
- abnormal vertebral column morphology
- arrhythmic circadian behavior persistence
- calcified calcaneal tendon
- calcified intervertebral disk
- calcified joint
- calcified tendon
- cataract
- corneal epithelium hyperplasia
- corneal vascularization
- decreased B cell number
- decreased IgG1 level
- decreased abdominal adipose tissue amount
- decreased basophil cell number
- decreased body size
- decreased body weight
- decreased circulating HDL cholesterol level
- decreased circulating VLDL triglyceride level
- decreased circulating adrenaline level
- decreased circulating glucose level
- decreased circulating insulin level
- decreased circulating noradrenaline level
- decreased circulating progesterone level
- decreased follicular B cell number
- decreased heart rate
- decreased heart weight
- decreased insulin secretion
- decreased kidney weight
- decreased leukocyte cell number
- decreased lung weight
- decreased lymphocyte cell number
- decreased mean systemic arterial blood pressure
- decreased muscle weight
- decreased pancreatic islet number
- decreased plasma anion gap
- decreased prothrombin time
- decreased spleen weight
- decreased subcutaneous adipose tissue amount
- decreased susceptibility to diet-induced obesity
- decreased testis weight
- decreased total body fat amount
- decreased transitional stage B cell number
- decreased uterus weight
- decreased vasodilation
- decreased white fat cell size
- dehydration
- delayed circadian behavior phase
- ectopic bone
- enlarged pancreatic islets
- failure of embryo implantation
- female infertility
- fragmentation of sleep/wake states
- fused joints
- hepatic steatosis
- hyperglycemia
- hypotension
- impaired gluconeogenesis
- impaired glucose tolerance
- impaired leukocyte tethering or rolling
- impaired righting response
- impaired wound healing
- increased blood urea nitrogen level
- increased bone resorption
- increased circulating HDL cholesterol level
- increased circulating LDL cholesterol level
- increased circulating VLDL cholesterol level
- increased circulating alanine transaminase level
- increased circulating aspartate transaminase level
- increased circulating cholesterol level
- increased circulating fibrinogen level
- increased circulating free fatty acid level
- increased circulating osteocalcin level
- increased circulating triglyceride level
- increased eosinophil cell number
- increased incidence of corneal inflammation
- increased insulin sensitivity
- increased leukocyte cell number
- increased liver triglyceride level
- increased lymphocyte cell number
- increased megakaryocyte cell number
- increased monocyte cell number
- increased neutrophil cell number
- increased osteoblast cell number
- increased partial thromboplastin time
- increased respiratory quotient
- increased sebum secretion
- increased total fat pad weight
- increased triglyceride level
- increased vasoconstriction
- infertility
- osteoporosis
- postnatal growth retardation
- premature aging
- premature death
- priapism
- prolonged estrous cycle
- retarded hair growth
- sacral vertebral fusion
- small seminal vesicle
- thoracic vertebral fusion
- thrombocytosis
- vascular smooth muscle hyperplasia
- weight loss
role in cell
- expression in
- activation in
- phosphorylation in
- production in
- differentiation
- size
- quantity
- number
- chondrogenesis
- cellular subpopulation ratio
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- intracellular membrane-bounded organelle
- Cytoplasm
- cytosol
- sister chromatids
- nucleoplasm
- nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arntl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of circadian rhythm
- regulation of hair cycle
- regulation of insulin secretion
- circadian regulation of gene expression
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- energy homeostasis
- regulation of cell cycle
- negative regulation of TOR signaling cascade
- regulation of cellular senescence
- oxidative stress-induced premature senescence
- spermatogenesis
- regulation of type B pancreatic cell development
- negative regulation of fat cell differentiation
- positive regulation of canonical Wnt receptor signaling pathway
- regulation of transcription, DNA-dependent
- circadian rhythm
- regulation of transcription from RNA polymerase II promoter
- response to redox state
- proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of skeletal muscle cell differentiation
- regulation of neurogenesis
- negative regulation of glucocorticoid receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatoid body
- PML body
- intracellular membrane-bounded organelle
- aryl hydrocarbon receptor complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- transcription cofactor activity
- aryl hydrocarbon receptor binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- Hsp90 protein binding
- protein dimerization activity
- E-box binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity