Csf1 Gene Summary [Mouse]
Enables macrophage colony-stimulating factor receptor binding activity and protein homodimerization activity. Involved in several processes, including macrophage colony-stimulating factor signaling pathway; microglial cell proliferation; and positive regulation of gene expression. Acts upstream of or within several processes, including macrophage homeostasis; mammary gland development; and positive regulation of myeloid leukocyte differentiation. Located in extracellular space. Part of CSF1-CSF1R complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and long bone. Used to study osteopetrosis. Human ortholog(s) of this gene implicated in interstitial cystitis. Orthologous to human CSF1 (colony stimulating factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Csf1 |
| Official Name | colony stimulating factor 1 (macrophage) [Source:MGI Symbol;Acc:MGI:1339753] |
| Ensembl ID | ENSMUSG00000014599 |
| Bio databases IDs | |
| Aliases | colony stimulating factor 1 (macrophage) |
| Synonyms | BAP025, colony stimulating factor 1, colony stimulating factor 1 (macrophage), CSF1 isoform 1, Csfm, M-CSF, MCSF1, Mhdabap25, op, PG-M-CSF |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Csf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Macrophage colony stimulating factor-1 (CSF-1)
- macrophage colony stimulating factor receptor binding
- ligand-binding domain
- protein homodimerization
- protein binding
- cytokine
- identical protein binding
- growth factor
Pathways
Biological processes and signaling networks where the Csf1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Altered T Cell and B Cell Signaling in Rheumatoid Arthritis
- Atherosclerosis Signaling
- Hematopoiesis from Multipotent Stem Cells
- Hematopoiesis from Pluripotent Stem Cells
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- Macropinocytosis Signaling
- MSP-RON Signaling Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of Tissue Factor in Cancer
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- metastasis
- epithelial cancer
- epithelial neoplasia
- cancer
- non-insulin-dependent diabetes mellitus
- neoplasia
- osteoporosis
- rheumatoid arthritis
- fibrosis
phenotypes
- abnormal Kupffer cell morphology
- abnormal Langerhans cell morphology
- abnormal Langerhans cell physiology
- abnormal auditory brainstem response
- abnormal auditory brainstem response waveform shape
- abnormal autopod morphology
- abnormal bone marrow cavity morphology
- abnormal bone marrow cell morphology/development
- abnormal bone marrow morphology
- abnormal bone remodeling
- abnormal bone structure
- abnormal branching of the mammary ductal tree
- abnormal circulating calcium level
- abnormal compact bone morphology
- abnormal dental follicle morphology
- abnormal dentin mineralization
- abnormal eating behavior
- abnormal femur morphology
- abnormal hematopoietic stem cell morphology
- abnormal lactation
- abnormal long bone hypertrophic chondrocyte zone
- abnormal mammary gland alveolus morphology
- abnormal mammary gland development
- abnormal mammary gland growth during lactation
- abnormal mammary gland growth during pregnancy
- abnormal mammary gland lobule morphology
- abnormal masseter muscle morphology
- abnormal mating frequency
- abnormal microglial cell morphology
- abnormal myeloid leukocyte morphology
- abnormal neurite morphology
- abnormal osteoblast morphology
- abnormal osteoblast physiology
- abnormal osteoclast cell number
- abnormal osteoclast differentiation
- abnormal osteoclast morphology
- abnormal osteocyte dendritic process morphology
- abnormal osteocyte lacuna morphology
- abnormal osteocyte morphology
- abnormal ovarian follicle number
- abnormal ovarian folliculogenesis
- abnormal ovary morphology
- abnormal ovulation
- abnormal parietal bone morphology
- abnormal perivascular macrophage morphology
- abnormal postnatal growth
- abnormal predentin morphology
- abnormal proestrus
- abnormal skeleton morphology
- abnormal sperm number
- abnormal spleen red pulp morphology
- abnormal splenic cell ratio
- abnormal splenocyte physiology
- abnormal testis physiology
- abnormal thyroid parafollicular C-cell morphology
- abnormal tibia morphology
- abnormal tooth root development
- abnormal trabecular bone morphology
- abnormal uterus development
- abnormal vestibular system physiology
- abnormal visual evoked potential
- absent Langerhans cell
- absent incisors
- absent teeth
- amyloid beta deposits
- decreased B cell number
- decreased body weight
- decreased bone marrow cell number
- decreased bone mineralization
- decreased bone resorption
- decreased circulating phosphate level
- decreased circulating testosterone level
- decreased compact bone thickness
- decreased corpora lutea number
- decreased fertilization frequency
- decreased hippocampus pyramidal cell number
- decreased length of long bones
- decreased leukocyte cell number
- decreased litter size
- decreased lymphocyte cell number
- decreased macrophage cell number
- decreased mature ovarian follicle number
- decreased monocyte cell number
- decreased osteoclast cell number
- decreased ovulation rate
- decreased physiological sensitivity to xenobiotic
- decreased secondary ovarian follicle number
- decreased spleen weight
- decreased susceptibility to atherosclerosis
- decreased trabecular bone thickness
- domed cranium
- endometrium hypoplasia
- extramedullary hematopoiesis
- failure of tooth eruption
- fragile skeleton
- impaired embryo implantation
- impaired granulosa cell differentiation
- impaired macrophage chemotaxis
- impaired osteoblast differentiation
- increased T cell number
- increased bone mass
- increased bone trabecula number
- increased granulocyte number
- increased long bone epiphyseal plate size
- increased osteocyte apoptosis
- increased testis weight
- increased trabecular bone mass
- increased trabecular bone volume
- increased width of hypertrophic chondrocyte zone
- myometrium hypoplasia
- necrospermia
- oligozoospermia
- osteopetrosis
- osteoporosis
- osteosclerosis
- postnatal growth retardation
- postnatal lethality incomplete penetrance
- premature death
- prolonged estrous cycle
- reduced female fertility
- reduced fertility
- reduced male fertility
- reduced male mating frequency
- round snout
- short limbs
- short tail
- slow postnatal weight gain
- small spleen
- thymus cortex hypoplasia
- thymus medulla atrophy
role in cell
- growth
- survival
- phosphorylation in
- expression in
- morphology
- activity
- apoptosis
- activation in
- quantity
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- perinuclear region
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- endoplasmic reticulum lumen
- nuclear bodies
- extracellular matrix
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Csf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell proliferation
- positive regulation of Ras protein signal transduction
- mammary duct terminal end bud growth
- branching involved in mammary gland duct morphogenesis
- positive regulation of multicellular organism growth
- monocyte activation
- osteoclast proliferation
- positive regulation of mononuclear cell proliferation
- positive regulation of protein metabolic process
- developmental process involved in reproduction
- inflammatory response
- response to ischemia
- positive regulation of osteoclast differentiation
- positive regulation of macrophage differentiation
- positive regulation of macrophage chemotaxis
- monocyte differentiation
- macrophage differentiation
- macrophage colony-stimulating factor signaling pathway
- transmembrane receptor protein tyrosine kinase signaling pathway
- Ras protein signal transduction
- positive regulation of odontogenesis of dentin-containing tooth
- neutrophil homeostasis
- mammary gland fat development
- positive regulation of monocyte differentiation
- osteoclast differentiation
- positive regulation of cell-matrix adhesion
- homeostasis of number of cells within a tissue
- positive regulation of protein kinase activity
- innate immune response
- positive regulation of gene expression
- regulation of macrophage derived foam cell differentiation
- monocyte homeostasis
- positive regulation of macrophage derived foam cell differentiation
- regulation of ossification
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- nuclear body
- perinuclear region of cytoplasm
- membrane
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- identical protein binding
- protein homodimerization activity
- protein binding
- cytokine activity
- macrophage colony-stimulating factor receptor binding