Spp1 Gene Summary [Mouse]
Enables extracellular matrix binding activity and integrin binding activity. Involved in bone mineralization and calcium ion homeostasis. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; intracellular chloride ion homeostasis; and intracellular monoatomic cation homeostasis. Located in apical part of cell and cytoplasm. Is expressed in several structures, including alimentary system; brain; metanephros; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; coronary artery disease (multiple); disease of cellular proliferation (multiple); and hepatitis. Orthologous to human SPP1 (secreted phosphoprotein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spp1 |
| Official Name | secreted phosphoprotein 1 [Source:MGI Symbol;Acc:MGI:98389] |
| Ensembl ID | ENSMUSG00000029304 |
| Bio databases IDs | |
| Aliases | secreted phosphoprotein 1 |
| Synonyms | 2AR, Apl-1, BNSP, Bone Sialoprotein, Bopn, Bsp, BSPI, Eta, ETA-1, LOC100359743, LOC100503439, NEPHROPONTIN, OP, OPN, OPNI, Opnl, OSP, OST, Osteopontin, OSTP, Ric, secreted phosphoprotein 1, SPP1 isoform 1, UROPONTIN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cryptic epitope
- binding protein
- thrombin cleavage site
- extracellular matrix binding
- integrin binding
- RGD motif
- protein binding
- cytokine
- Osteopontin
- integrin binding domain
Pathways
Biological processes and signaling networks where the Spp1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- epithelial neoplasia
- benign neoplasia
- cancer
- abdominal cancer
- epithelial cancer
- experimental autoimmune encephalomyelitis
- neoplasia
- metastatic breast cancer
- infection
phenotypes
- abnormal eyelid morphology
- anophthalmia
- corneal deposits
- corneal opacity
- corneal vascularization
- exophthalmos
- eye hemorrhage
- eyelids fail to open
- narrow eye opening
- sclerocornea
- abnormal blood cell morphology/development
- abnormal blood flow velocity
- abnormal blood vessel morphology
- abnormal blood vessel physiology
- abnormal bone mineralization
- abnormal cardiovascular system physiology
- abnormal chemokine level
- abnormal hematopoietic system physiology
- abnormal immune system physiology
- abnormal inflammatory response
- abnormal leukocyte migration
- abnormal leukocyte physiology
- abnormal liver morphology
- abnormal long bone metaphysis morphology
- abnormal macrophage chemotaxis
- abnormal macrophage morphology
- abnormal macrophage physiology
- abnormal microglial cell morphology
- abnormal osteoblast physiology
- abnormal osteoclast physiology
- abnormal physiological neovascularization
- abnormal response to infection
- abnormal striatum morphology
- abnormal substantia nigra morphology
- abnormal vascular wound healing
- abnormal vasodilation
- abnormal wound healing
- altered response to myocardial infarction
- altered susceptibility to infection
- calcified aortic valve
- crystalluria
- decreased acute inflammation
- decreased bone resorption
- decreased cardiac muscle contractility
- decreased circulating glucose level
- decreased circulating insulin level
- decreased circulating interleukin-6 level
- decreased circulating triglyceride level
- decreased dendritic cell number
- decreased fibroblast chemotaxis
- decreased heart weight
- decreased hematocrit
- decreased hemoglobin content
- decreased incidence of tumors by chemical induction
- decreased interferon-gamma secretion
- decreased interleukin-12 secretion
- decreased lean body mass
- decreased leukocyte cell number
- decreased macrophage cell number
- decreased osteoclast cell number
- decreased physiological sensitivity to xenobiotic
- decreased sensitivity to induced cell death
- decreased susceptibility to Herpesvirales infection
- decreased susceptibility to atherosclerosis
- decreased susceptibility to bacterial infection
- decreased susceptibility to bacterial infection induced morbidity/mortality
- decreased susceptibility to dopaminergic neuron neurotoxicity
- decreased susceptibility to experimental autoimmune uveoretinitis
- decreased susceptibility to type IV hypersensitivity reaction
- decreased systemic arterial blood pressure
- decreased systemic arterial systolic blood pressure
- decreased tumor necrosis factor secretion
- decreased urine chloride ion level
- decreased urine sodium level
- delayed wound healing
- dilated renal tubules
- granulomatous inflammation
- hyporesponsive to tactile stimuli
- impaired macrophage chemotaxis
- improved glucose tolerance
- increased blood urea nitrogen level
- increased bone marrow cell number
- increased bone mineral density
- increased circulating creatinine level
- increased heart rate
- increased hematopoietic stem cell number
- increased insulin sensitivity
- increased interleukin-10 secretion
- increased interleukin-4 secretion
- increased lung weight
- increased lymphocyte cell number
- increased macrophage cell number
- increased neuron number
- increased osteoclast cell number
- increased physiological sensitivity to xenobiotic
- increased respiratory quotient
- increased sensitivity to induced morbidity/mortality
- increased susceptibility to bacterial infection
- increased susceptibility to injury
- increased trabecular bone thickness
- lung cysts
- nephrocalcinosis
- renal tubular necrosis
role in cell
- expression in
- binding in
- growth
- differentiation
- glycolysis in
- apoptosis
- chemotaxis
- binding
- activation in
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- perimembrane region
- clear zone
- Cytoplasm
- cell surface
- intracellular space
- apical compartment
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- endoplasmic reticulum lumen
- basolateral membrane
- ruffled borders
- extracellular matrix
- cellular protrusions
- dendrites
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to vitamin D
- signal transduction
- decidualization
- cell adhesion
- response to steroid hormone stimulus
- androgen catabolic process
- embryo implantation
- cellular response to testosterone stimulus
- positive regulation of estradiol secretion
- positive regulation of transcription, DNA-dependent
- negative regulation of collateral sprouting of intact axon in response to injury
- positive regulation of bone resorption
- osteoblast differentiation
- response to macrophage colony-stimulating factor stimulus
- biomineral tissue development
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- Golgi apparatus
- extracellular region
- cell projection
Molecular Function
What the gene product does at the molecular level
- extracellular matrix binding
- protein binding
- small molecule binding
- integrin binding
- cytokine activity