Scd1 Gene Summary [Mouse]
Enables metal ion binding activity; palmitoyl-CoA 9-desaturase activity; and stearoyl-CoA 9-desaturase activity. Involved in several processes, including positive regulation of cold-induced thermogenesis; sterol homeostasis; and tarsal gland development. Acts upstream of or within several processes, including brown fat cell differentiation; monounsaturated fatty acid biosynthetic process; and white fat cell differentiation. Located in endoplasmic reticulum membrane. Is expressed in several structures, including adipose tissue; central nervous system; cranium; integumental system; and liver. Orthologous to human SCD (stearoyl-CoA desaturase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Scd1 |
| Official Name | stearoyl-Coenzyme A desaturase 1 [Source:MGI Symbol;Acc:MGI:98239] |
| Ensembl ID | ENSMUSG00000037071 |
| Bio databases IDs | |
| Aliases | stearoyl-Coenzyme A desaturase 1 |
| Synonyms | ab, Delta9 Desaturase, Scd, Stearoyl-CoA desaturase, stearoyl-Coenzyme A desaturase 1, Stearyl CoA Destaurase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Scd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- stearoyl-CoA 9-desaturase
- Membrane-FADS-like
- oxidoreductase
- Fatty acid desaturase
- metal ion binding
- CoA desaturase
- iron ion binding
- enzyme
Pathways
Biological processes and signaling networks where the Scd1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- hypercholesterolemia
- epithelial cancer
- hyperglycemia
- obesity
- skin barrier defect
- insulin resistance
- weight gain
- hypoplasia
- hepatic steatosis
phenotypes
- Meibomian gland atrophy
- abnormal cholesterol homeostasis
- abnormal cutaneous collagen fibril morphology
- abnormal cutaneous elastic fiber morphology
- abnormal dermal layer morphology
- abnormal eating behavior
- abnormal estrous cycle
- abnormal glucose homeostasis
- abnormal hair cycle
- abnormal hair follicle bulb morphology
- abnormal hair follicle development
- abnormal hair follicle inner root sheath morphology
- abnormal hair follicle morphology
- abnormal hair follicle outer root sheath morphology
- abnormal hair growth
- abnormal hair shaft morphology
- abnormal lipid level
- abnormal metabolism
- abnormal piliary canal morphology
- abnormal reproductive system physiology
- abnormal sebaceous lipid secretion
- abnormal sebocyte morphology
- abnormal skin condition
- abnormal skin morphology
- abnormal skin physiology
- abnormal skin sebaceous gland morphology
- acanthosis
- alopecia
- blindness
- decreased circulating glucose level
- decreased circulating insulin level
- decreased circulating triglyceride level
- decreased hair follicle number
- decreased liver triglyceride level
- decreased percent body fat/body weight
- decreased skin tensile strength
- decreased susceptibility to diet-induced obesity
- decreased susceptibility to hepatic steatosis
- decreased unsaturated fatty acid level
- decreased white adipose tissue amount
- distorted hair follicle pattern
- dry skin
- enlarged hair follicles
- eyelids fail to open
- flaky skin
- granulomatous inflammation
- hunched posture
- hyperkeratosis
- impaired skin barrier function
- improved glucose tolerance
- increased circulating ketone body level
- increased fluid intake
- increased insulin sensitivity
- increased oxygen consumption
- increased saturated fatty acid level
- increased susceptibility to bacterial infection
- matted coat
- narrow eye opening
- orthokeratosis
- parakeratosis
- photophobia
- polyphagia
- polyuria
- postnatal growth retardation
- progressive hair loss
- prolonged diestrus
- reduced female fertility
- scaly skin
- sebaceous gland atrophy
- sebaceous gland hypoplasia
- short hair
- small Meibomian gland
- small perianal sebaceous gland
- small sebaceous gland
- sparse hair
- spontaneous skin ulceration
- thick dermal layer
- thick epidermis
- wrinkled skin
role in cell
- apoptosis
- quantity
- phosphorylation in
- expression in
- differentiation
- accumulation in
- migration
- activation in
- production in
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum fraction
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- mitochondria-associated membranes
- nucleoli