Dgat2 Gene Summary [Mouse]
Enables 2-acylglycerol O-acyltransferase activity; diacylglycerol O-acyltransferase activity; and protein homodimerization activity. Involved in several processes, including acylglycerol biosynthetic process; cellular response to oleic acid; and cholesterol homeostasis. Located in endoplasmic reticulum membrane and perinuclear region of cytoplasm. Colocalizes with lipid droplet and mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in metabolic dysfunction-associated steatotic liver disease. Orthologous to human DGAT2 (diacylglycerol O-acyltransferase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dgat2 |
| Official Name | diacylglycerol O-acyltransferase 2 [Source:MGI Symbol;Acc:MGI:1915050] |
| Ensembl ID | ENSMUSG00000030747 |
| Bio databases IDs | |
| Aliases | diacylglycerol O-acyltransferase 2 |
| Synonyms | 0610010B06Rik, ARAT, diacylglycerol O-acyltransferase 2, GS1999FULL, HMFN1045 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dgat2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
- 2-acylglycerol O-acyltransferase
- diacylglycerol O-acyltransferase
- protein homodimerization
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- hypoglycemia
- skin barrier defect
- orthokeratosis
- systemic lupus erythematosus
- hepatic insulin resistance
- ichthyosis
- dry skin
- colorectal adenoma
- colorectal adenoma formation
role in cell
- quantity
- ferroptosis
- production in
- abnormal morphology
- response by
- accumulation
- accumulation in
- gluconeogenesis in
- storage in
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- perinuclear region
- cellular membrane
- Endoplasmic Reticulum
- Mitochondria
- lipid droplets
- cytosol
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dgat2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- low-density lipoprotein particle clearance
- glycerol metabolic process
- lipid storage
- fatty acid homeostasis
- monoacylglycerol biosynthetic process
- diacylglycerol biosynthetic process
- retinol metabolic process
- fat pad development
- cholesterol homeostasis
- diacylglycerol metabolic process
- regulation of plasma lipoprotein particle levels
- triglyceride biosynthetic process
- cellular response to oleic acid
- cellular triglyceride homeostasis
- long-chain fatty-acyl-CoA metabolic process
Cellular Component
Where in the cell the gene product is active
- lipid particle
- endoplasmic reticulum membrane
- perinuclear region of cytoplasm
- intracellular membrane-bounded organelle
- membrane
- mitochondrion
- cytosol
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- 2-acylglycerol O-acyltransferase activity
- retinol O-fatty-acyltransferase activity
- diacylglycerol O-acyltransferase activity