Qk Gene Summary [Mouse]
Enables mRNA 3'-UTR binding activity and transcription coactivator activity. Involved in several processes, including negative regulation of metabolic process; regulation of glial cell differentiation; and regulation of mRNA metabolic process. Acts upstream of or within several processes, including long-chain fatty acid biosynthetic process; spermatid development; and vasculature development. Located in cytoplasm and nucleus. Is active in synapse. Is expressed in several structures, including central nervous system; craniocervical region bone; reproductive system; sensory organ; and yolk sac. Orthologous to human QKI (QKI, KH domain containing RNA binding). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Qk |
| Official Name | quaking, KH domain containing RNA binding [Source:MGI Symbol;Acc:MGI:97837] |
| Ensembl ID | ENSMUSG00000062078 |
| Bio databases IDs | |
| Aliases | quaking, KH domain containing RNA binding |
| Synonyms | 1110003F05Rik, 1500005P18, Hqk, hqkI, l(17)-1Wis, l17Wis1, LOC108348175, LOC684079, QK, QK1, QK3, QKI, KH domain containing RNA binding, quaking, KH domain containing RNA binding |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Qk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Qua1 domain
- transcription co-activator
- STAR-NLS
- mRNA binding
- protein binding activity, bridging
- Putative nuclear localization signal of quaking
- protein binding
- RNA binding
- Qua2 domain
- mRNA 3' UTR binding
- STAR domain
- K homology (KH) RNA-binding domain, type I
- Homodimerization region of STAR domain protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- multiple sclerosis
- weight gain
- breast cancer
- schizophrenia
- insomnia
- lung cancer
- Alzheimer disease
- metastasis
- non-insulin-dependent diabetes mellitus
role in cell
- apoptosis
- production in
- number
- expression in
- quantity
- differentiation
- phosphorylation in
- replication in
- proliferation
- G1 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoli
- synapse
- stress granule
- membrane processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Qk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- microglia differentiation
- RNA splicing
- regulation of macrophage differentiation
- long-chain fatty acid biosynthetic process
- intracellular mRNA localization
- spermatid development
- myelination
- regulation of astrocyte differentiation
- mRNA processing
- vasculogenesis
- positive regulation of oligodendrocyte differentiation
- regulation of epithelial to mesenchymal transition
- positive regulation of gene expression
- regulation of nuclear mRNA splicing, via spliceosome
- negative regulation of translation
- vascular smooth muscle cell differentiation
- mRNA transport
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasmic stress granule
- cytosol
- synapse
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA binding
- mRNA binding
- SH3 domain binding
- mRNA 3'-UTR binding