Elavl2 Gene Summary [Mouse]
Predicted to enable RNA binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Is active in synapse. Is expressed in several structures, including early embryo; gut; nervous system; ovary; and sensory organ. Orthologous to human ELAVL2 (ELAV like RNA binding protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Elavl2 |
| Official Name | ELAV like RNA binding protein 1 [Source:MGI Symbol;Acc:MGI:1100887] |
| Ensembl ID | ENSMUSG00000008489 |
| Bio databases IDs | |
| Aliases | ELAV like RNA binding protein 1 |
| Synonyms | Elav2, ELAV like RNA binding protein 1, ELAV like RNA binding protein 2, Embryonic lethal abnormal vision like 2, HEL-N1, HEL N2, HU-antigen B, HUB, mel-N1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Elavl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ELAV/HuD family splicing factor
- RNA recognition motif (RRM) superfamily
- mRNA 3' UTR binding
- RNA recognition motif
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- schizophrenia
- insomnia
- depressive disorder
- epithelial cancer
- pervasive developmental disorder
- irritable bowel syndrome
- growth failure
- neuroticism
- major depression
role in cell
- expression in
- differentiation
- loss
- degeneration
- lack
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- polyribosome fractions
- glutaminergic synapse
- ribosome
- synapse
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Elavl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription, DNA-dependent
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- mRNA 3'-UTR binding