Adk Gene Summary [Mouse]
Enables adenosine kinase activity and deoxyadenosine kinase activity. Involved in AMP salvage; GMP salvage; and dAMP salvage. Acts upstream of or within dATP biosynthetic process and purine ribonucleoside salvage. Located in nucleus. Is active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Used to study steatotic liver disease. Human ortholog(s) of this gene implicated in hypermethioninemia due to adenosine kinase deficiency. Orthologous to human ADK (adenosine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adk |
| Official Name | adenosine kinase [Source:MGI Symbol;Acc:MGI:87930] |
| Ensembl ID | ENSMUSG00000039197 |
| Bio databases IDs | |
| Aliases | adenosine kinase |
| Synonyms | 2310026J05RIK, 5033405D03Rik, Adenosine kinase, AK |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- ribokinase_pfkB_like
- adenosine kinase
- ribokinase
- 5-dehydro-2-deoxygluconokinase
- pfkB family carbohydrate kinase
- deoxyadenosine kinase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- coronary artery disease
- metabolic syndrome X
- cardiovascular disorder
- insulin resistance
- non-insulin-dependent diabetes mellitus
- epithelial cancer
- cancer
- hepatitis C
- fibrosis
role in cell
- expression in
- apoptosis
- proliferation
- survival
- differentiation
- phosphorylation in
- cytostasis
- conversion in
- activity
- osteoclastogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Plasma Membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- AMP salvage
- ribonucleoside monophosphate biosynthetic process
- GMP salvage
- dATP biosynthetic process
- purine ribonucleoside salvage
- purine base metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- RNA binding
- metal ion binding
- adenosine kinase activity
- deoxyadenosine kinase activity