Trp53 Gene Summary [Mouse]
This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mice deficient for this gene are developmentally normal but are susceptible to spontaneous tumors. Evidence to date shows that this gene contains one promoter, in contrast to alternative promoters of the human gene, and transcribes a few of splice variants which encode different isoforms, although the biological validity or the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Trp53 |
| Official Name | transformation related protein 53 [Source:MGI Symbol;Acc:MGI:98834] |
| Ensembl ID | ENSMUSG00000059552 |
| Bio databases IDs | |
| Aliases | transformation related protein 53 |
| Synonyms | bbl, BCC7, bfy, bhy, BMFS5, LFS1, LFS3, p44, P53, P53 cellular tumour antigen, p53 tumor suppressor, transformation related protein 53, TRP53, tumor protein p53, tumour protein p53 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trp53 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone deacetylase regulator
- C-terminal regulatory domain
- A/B region
- protein binding activity, bridging
- P53 DNA-binding domain
- transcription factor binding
- core domain, functional
- identical protein binding
- PML binding domain
- HPV-16 E2 protein binding domain
- Transactivation domain 2
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- receptor tyrosine kinase binding
- proline and tyrosine-rich region
- serine phosphorylation site
- chaperone binding
- basic domain
- core domain, structural
- ubiquitin protein ligase binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- TAD2 subdomain
- AD1 domain
- nuclear export signal
- loop-sheet-helix domain
- DNA binding domain
- protease binding
- nucleic acid binding
- protein phosphatase binding
- TBP binding domain
- BOX-V domain
- p53 core domain
- protein binding
- sequence-specific DNA binding
- polyproline motif
- acidic domain
- TAD1 subdomain
- Mdm2 protein binding domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- N-terminal transactivation domain
- mRNA 3' UTR binding
- minimal transactivation domain
- ATM phosphorylation site
- C-terminal oligomerization domain
- transcription factor activity
- extreme C-terminal domain
- protein heterodimerization
- transcription regulator
- LXXLL motif
- P53 transactivation motif
- regulatory domain
- homo-oligomerization domain
- transcription activation domain
- chromatin binding
- cytoplasmic sequestration domain
- Jnk-binding domain
- enzyme
- proline rich domain
- Sh3 domain binding motif
- docking domain
- copper ion binding
- Box I domain
- zinc ion binding
- ion channel binding
- Casein Kinase 2 beta binding domain
- AD2 domain
- sequence-specific DNA binding domain
- lysine rich domain
- acetylation site
- tetramerization domain
- oligomerization domain
- BRCA1-binding domain
- P53 tetramerization motif
- negative regulatory domain
- nuclear localization sequence
- enzyme binding
- histone deacetylase binding
- isomerase
- protein domain specific binding
- central domain
- p53 binding
- DNA dependent ATPase
- activation domain AD1
- S100B binding domain
- DNA binding
- phosphorylation site
- beta strand or sheet
- p300/cbp binding domain
- transcription repression domain
- binding protein
- single-stranded DNA binding
- double-stranded DNA binding
- replication protein A binding domain
- NDB domain
- zinc finger domain
- PXXP motif
Pathways
Biological processes and signaling networks where the Trp53 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- non-small cell lung cancer
- metastatic breast cancer
- plasma cell myeloma
- metastasis
- lung cancer
- breast cancer
- secondary neoplasm
- non-insulin-dependent diabetes mellitus
- hepatocellular carcinoma
phenotypes
- abnormal retina morphology
- increased blood urea nitrogen level
- increased large unstained cell number
- increased startle reflex
- persistence of hyaloid vascular system
- preweaning lethality incomplete penetrance
- abnormal DNA replication
- abnormal Peyer's patch morphology
- abnormal abdominal lymph node morphology
- abnormal apoptosis
- abnormal cardiovascular system physiology
- abnormal cell cycle
- abnormal cell cycle checkpoint function
- abnormal cell death
- abnormal cell physiology
- abnormal cell proliferation
- abnormal cerebellar Purkinje cell layer
- abnormal cerebellar cortex morphology
- abnormal cerebellar foliation
- abnormal chromosome number
- abnormal coat/ hair morphology
- abnormal common myeloid progenitor cell morphology
- abnormal definitive hematopoiesis
- abnormal digit pigmentation
- abnormal enterocyte apoptosis
- abnormal hematopoietic stem cell physiology
- abnormal hematopoietic system physiology
- abnormal limb morphology
- abnormal lymphocyte morphology
- abnormal male germ cell apoptosis
- abnormal mammary gland development
- abnormal megakaryocyte progenitor cell morphology
- abnormal mesenchyme morphology
- abnormal neuron differentiation
- abnormal ocular fundus morphology
- abnormal optic nerve morphology
- abnormal physiological response to xenobiotic
- abnormal posterior eye segment morphology
- abnormal retinal vasculature morphology
- abnormal spermatogenesis
- abnormal spine curvature
- abnormal spleen marginal zone morphology
- abnormal spleen morphology
- abnormal spleen white pulp morphology
- abnormal startle reflex
- abnormal tail tip morphology
- abnormal thymocyte apoptosis
- abnormal thymus morphology
- abnormal thymus physiology
- abnormal tibia morphology
- abnormal tongue morphology
- abnormal tumor incidence
- abnormal tumor latency
- abnormal tumor morphology
- absent cerebellum vermis
- absent optic nerve
- adipose tissue inflammation
- altered response to myocardial infarction
- anemia
- aneuploidy
- ataxia
- cardiac hypertrophy
- cerebellum hypoplasia
- chromosomal instability
- colon polyps
- darkened coat color
- decreased T cell apoptosis
- decreased T cell proliferation
- decreased apoptosis
- decreased body size
- decreased body weight
- decreased bone marrow cell number
- decreased bone mineral density
- decreased brain size
- decreased cell proliferation
- decreased cellular sensitivity to gamma-irradiation
- decreased cellular sensitivity to ionizing radiation
- decreased cellular sensitivity to ultraviolet irradiation
- decreased circulating insulin-like growth factor I level
- decreased common myeloid progenitor cell number
- decreased erythrocyte cell number
- decreased erythroid progenitor cell number
- decreased fibroblast apoptosis
- decreased hematocrit
- decreased hematopoietic stem cell number
- decreased hematopoietic stem cell proliferation
- decreased incidence of tumors by chemical induction
- decreased kidney weight
- decreased leukocyte cell number
- decreased liver weight
- decreased mortality induced by ionizing radiation
- decreased neuron apoptosis
- decreased neuronal precursor cell number
- decreased neutrophil cell number
- decreased sensitivity to induced cell death
- decreased sensitivity to induced morbidity/mortality
- decreased sensitivity to skin irradiation
- decreased skeletal muscle mass
- decreased spleen red pulp amount
- decreased spleen weight
- decreased splenocyte apoptosis
- decreased subcutaneous adipose tissue amount
- decreased survivor rate
- decreased telomere length
- decreased testis weight
- decreased thymocyte apoptosis
- decreased tumor growth/size
- decreased tumor incidence
- decreased tumor latency
- delayed cellular replicative senescence
- delayed hair regrowth
- delayed wound healing
- embryonic lethality during organogenesis complete penetrance
- embryonic lethality during organogenesis incomplete penetrance
- enlarged heart
- enlarged liver
- enlarged spleen
- exencephaly
- extramedullary hematopoiesis
- gastric polyps
- hemorrhage
- hepatic steatosis
- increased B cell derived lymphoma incidence
- increased T cell derived lymphoma incidence
- increased adenocarcinoma incidence
- increased adenoma incidence
- increased angiogenesis
- increased brain size
- increased brain tumor incidence
- increased carcinoma incidence
- increased cell proliferation
- increased cellular glucose import
- increased cellular sensitivity to DNA damaging agents
- increased cellular sensitivity to ionizing radiation
- increased cellular sensitivity to ultraviolet irradiation
- increased circulating interferon-gamma level
- increased circulating interleukin-3 level
- increased circulating interleukin-5 level
- increased circulating interleukin-6 level
- increased circulating tumor necrosis factor level
- increased enterocyte apoptosis
- increased fibroblast proliferation
- increased fibrosarcoma incidence
- increased follicular lymphoma incidence
- increased foot pad pigmentation
- increased hamartoma incidence
- increased heart weight
- increased hemangioma incidence
- increased hemangiosarcoma incidence
- increased hematopoietic stem cell number
- increased hepatocellular carcinoma incidence
- increased hibernoma incidence
- increased histiocytic sarcoma incidence
- increased incidence of tumors by chemical induction
- increased incidence of tumors by ionizing radiation induction
- increased inflammatory response
- increased intestinal adenoma incidence
- increased leiomyosarcoma incidence
- increased leukemia incidence
- increased lipoma incidence
- increased liver tumor incidence
- increased lung adenocarcinoma incidence
- increased lung adenoma incidence
- increased lymphoma incidence
- increased mammary adenocarcinoma incidence
- increased medulloblastoma incidence
- increased metastatic potential
- increased mortality induced by gamma-irradiation
- increased mortality induced by ionizing radiation
- increased osteosarcoma incidence
- increased ovary tumor incidence
- increased pancreas tumor incidence
- increased pro-B cell number
- increased reproductive system tumor incidence
- increased rhabdomyosarcoma incidence
- increased sarcoma incidence
- increased sensitivity to induced cell death
- increased sensitivity to xenobiotic induced morbidity/mortality
- increased skin papilloma incidence
- increased skin tumor incidence
- increased spindle cell carcinoma incidence
- increased splenic marginal zone lymphoma incidence
- increased splenocyte proliferation
- increased squamous cell carcinoma incidence
- increased tail pigmentation
- increased teratocarcinoma incidence
- increased teratoma incidence
- increased testicular teratoma incidence
- increased thymocyte apoptosis
- increased tumor incidence
- increased tumor latency
- increased urinary system tumor incidence
- intestinal ulcer
- intestine polyps
- kinked tail
- kyphosis
- lethality throughout fetal growth and development incomplete penetrance
- lethality incomplete penetrance
- lethargy
- liver cirrhosis
- liver hyperplasia
- liver hypoplasia
- liver inflammation
- lordosis
- lung inflammation
- muscular atrophy
- nail dystrophy
- no abnormal phenotype detected
- opacity of vitreous body
- optic nerve degeneration
- optic nerve hypoplasia
- oral leukoplakia
- osteopetrosis
- oxidative stress
- pallor
- pancytopenia
- polyploidy
- postnatal growth retardation
- postnatal lethality complete penetrance
- postnatal lethality incomplete penetrance
- premature aging
- premature death
- prenatal lethality incomplete penetrance
- preweaning lethality complete penetrance
- pulmonary fibrosis
- renal hypoplasia
- skin lesions
- small gonad
- small spleen
- small testis
- small thymus
- sparse hair
- spleen hyperplasia
- spleen hypoplasia
- spontaneous chromosome breakage
- testis hypoplasia
- thin cerebellar granule layer
- thin dermal layer
- thrombocytopenia
- vasculitis
- weight loss
role in cell
- replication in
- expression in
- activation
- binding
- adhesion
- binding in
- colony formation
- cell death
- survival
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- soluble fraction
- aggresome
- perinuclear body
- cytoskeleton
- Cytoplasm
- intracellular space
- perinuclear region
- Plasma Membrane
- centrosome
- Endoplasmic Reticulum
- Mitochondria
- microtubules
- cytoplasmic particles
- cytoplasmic aggregates
- metaphase plate
- cytosol
- mitochondria-associated membranes
- mitochondrial matrix
- nuclear foci
- perinucleolar compartments
- nucleoplasm
- perinuclear space
- nucleoli
- nuclear bodies
- nuclear speckles
- nuclear matrix
- mitoplasts
- DNA replication foci
- PML nuclear bodies
- mitotic spindle
- chromatin
- replication fork
- perikaryon
- plasma
- detergent-soluble fraction
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trp53 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial DNA repair
- determination of adult lifespan
- protein localization
- nucleotide-excision repair
- DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
- T cell lineage commitment
- circadian behavior
- hemopoietic progenitor cell differentiation
- oligodendrocyte apoptotic process
- cellular response to UV-C
- neuroblast proliferation
- negative regulation of neuroblast proliferation
- negative regulation of transcription, DNA-dependent
- cardiac muscle cell apoptotic process
- in utero embryonic development
- positive regulation of transcription, DNA-dependent
- negative regulation of cell growth
- regulation of tissue remodeling
- neuron apoptotic process
- regulation of DNA damage response, signal transduction by p53 class mediator
- positive regulation of mitochondrial membrane permeability
- positive regulation of gene expression, epigenetic
- macromolecular complex assembly
- cerebellum development
- Ras protein signal transduction
- response to DNA damage stimulus
- cellular response to glucose starvation
- positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
- cellular response to gamma radiation
- negative regulation of stem cell proliferation
- signal transduction by p53 class mediator resulting in induction of apoptosis
- negative regulation of helicase activity
- protein import into nucleus
- signal transduction by p53 class mediator
- release of cytochrome c from mitochondria
- positive regulation of cardiac muscle cell apoptotic process
- multicellular organism growth
- response to salt stress
- replicative senescence
- negative regulation of cell proliferation
- cellular senescence
- intrinsic apoptotic signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of neuron apoptotic process
- bone marrow development
- double-strand break repair
- fibroblast proliferation
- negative regulation of fibroblast proliferation
- protein tetramerization
- stem cell proliferation
- positive regulation of cellular senescence
- positive regulation of peptidyl-tyrosine phosphorylation
- positive regulation of reactive oxygen species metabolic process
- negative regulation of reactive oxygen species metabolic process
- negative regulation of glial cell proliferation
- T cell differentiation in thymus
- mitotic cell cycle G1/S transition DNA damage checkpoint
- positive regulation of release of cytochrome c from mitochondria
- rRNA transcription
- cardiac septum morphogenesis
- gastrulation
- reactive oxygen species metabolic process
- chromosome organization
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
- negative regulation of transforming growth factor beta receptor signaling pathway
- regulation of fibroblast apoptotic process
- transforming growth factor beta receptor signaling pathway
- autophagy
- entrainment of circadian clock by photoperiod
- thymocyte apoptotic process
- positive regulation of thymocyte apoptotic process
- cellular response to hypoxia
- regulation of cell cycle
- response to gamma radiation
- positive regulation of intrinsic apoptotic signaling pathway
- embryonic organ development
- regulation of apoptotic process
- negative regulation of DNA replication
- macromitophagy
- tumor necrosis factor-mediated signaling pathway
- B cell lineage commitment
- somitogenesis
- positive regulation of gene expression
- DNA damage response, signal transduction by p53 class mediator
- response to X-ray
- mRNA transcription
- response to antibiotic
- negative regulation of proteolysis
- ER overload response
- positive regulation of execution phase of apoptosis
- negative regulation of transcription from RNA polymerase II promoter
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
- response to ischemia
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
- necroptosis
- glucose catabolic process to lactate via pyruvate
- cellular response to UV
- viral reproduction
- cellular response to ionizing radiation
- oxidative stress-induced premature senescence
- cellular response to actinomycin D
- interferon-gamma-mediated signaling pathway
- hemopoietic stem cell differentiation
- regulation of transcription, DNA-dependent
- regulation of transcription from RNA polymerase II promoter
- negative regulation of apoptotic process
- positive regulation of apoptotic process
- T cell proliferation involved in immune response
- cellular response to xenobiotic stimulus
- glial cell proliferation
- negative regulation of telomere maintenance via telomerase
- protein stabilization
Cellular Component
Where in the cell the gene product is active
- nuclear body
- site of double-strand break
- PML body
- endoplasmic reticulum
- nucleolus
- chromatin
- nucleoplasm
- replication fork
- nucleus
- transcription factor complex
- germ cell nucleus
- centrosome
- cytoplasm
- mitochondrial matrix
- transcriptional repressor complex
- mitochondrion
- cytosol
- nuclear matrix
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- protease binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- mRNA 3'-UTR binding
- sequence-specific DNA binding transcription factor activity
- p53 binding
- copper ion binding
- protein heterodimerization activity
- chaperone binding
- TFIID-class transcription factor binding
- protein phosphatase 2A binding
- histone deacetylase regulator activity
- identical protein binding
- zinc ion binding
- histone deacetylase binding
- core promoter proximal region sequence-specific DNA binding
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- core promoter sequence-specific DNA binding
- DNA binding
- ubiquitin protein ligase binding
- protein binding
- receptor tyrosine kinase binding
- enzyme binding
- 14-3-3 protein binding