Ube3c Gene Summary [Mouse]
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein K29-linked ubiquitination; protein K48-linked ubiquitination; and ubiquitin-dependent protein catabolic process. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human UBE3C (ubiquitin protein ligase E3C). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ube3c |
| Official Name | ubiquitin protein ligase E3C [Source:MGI Symbol;Acc:MGI:2140998] |
| Ensembl ID | ENSMUSG00000039000 |
| Bio databases IDs | |
| Aliases | ubiquitin protein ligase E3C |
| Synonyms | HECTH2, KIAA0010, KIAA10, mKIAA0010, NDSMBA, NEDSMBA, RAUL, RGD1559986, Ubiquitin Protein Isopeptide Ligase E3, ubiquitin protein ligase E3C |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ube3c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HECTc
- Calmodulin-binding motif
- ubiquitin protein ligase activity
- Domain Homologous to E6-AP Carboxyl Terminus with
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- neoplasia
- diabetes mellitus
- lung squamous cell carcinoma
- squamous cell lung cancer
- neurodevelopmental disorder with absent speech and movement and behavioral abnormalities
- headache
- diabetic neuropathy
- metabolic syndrome X
- diabetic retinopathy
phenotypes
- abnormal caudal vertebrae morphology
- abnormal gait
- abnormal heart left ventricle morphology
- decreased CD4-negative NK T cell number
- decreased CD4-positive NK T cell number
- decreased CD5-positive Ly6C-positive T cell number
- decreased Ly6C-positive NK T cell number
- decreased Ly6C-positive immature NK cell number
- decreased NK T cell number
- decreased body length
- decreased bone mineral content
- decreased bone mineral density
- decreased cardiac output
- decreased cardiac stroke volume
- decreased circulating bilirubin level
- decreased circulating iron level
- decreased circulating serum albumin level
- decreased exploration in new environment
- decreased food intake
- decreased heart weight
- decreased memory-marker CD4-negative NK T cell number
- decreased memory-marker CD4-positive NK T cell number
- decreased prepulse inhibition
- decreased respiratory quotient
- decreased total retina thickness
- decreased vertical activity
- immune system phenotype
- increased blood urea nitrogen level
- increased bone mineral content
- increased circulating alkaline phosphatase level
- increased circulating amylase level
- increased circulating cholesterol level
- increased circulating triglyceride level
- increased effector memory CD8-positive alpha-beta T cell number
- increased leukocyte cell number
- increased lymphocyte cell number
- increased total body fat amount
- short tibia
- abnormal adipose tissue amount
- abnormal body length
- abnormal bone mineral density
- abnormal bone mineralization
- abnormal circulating alkaline phosphatase level
- abnormal food intake
- abnormal respiratory quotient
- abnormal tibia morphology
role in cell
- expression in
- degradation in
- replication in
- radioresistance
- tanespimycin sensitivity
- radiosensitivity
- transcription in
- endoplasmic reticulum-associated degradation in
- K48 polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ube3c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein K48-linked ubiquitination
- protein K29-linked ubiquitination
- protein polyubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- proteasome complex
Molecular Function
What the gene product does at the molecular level
- protein binding