Target List
Anaplastic Glial Tumors
CDKN2A (P16INK4A), CDKN2B (p15INK4b), MDM2, PTEN, RB1, TP53 (p53)
Astrocytomas
ATRX, BRAF, CHEK2 (RAD53), FGFR1, IDH1, IDH2, KRAS, NOTCH1, PTPN11, RB1, TP53 (p53)
Ependymomas
CDKN2A (P16INK4A), CDKN2B (p15INK4b), H3-3A, NF2, NOTCH1
Glioblastomas
ALK, APC, BCOR, BRAF, CDK4, CDK6, CDKN2A (P16INK4A), CDKN2B (p15INK4b), CREBBP (CBP), EGFR (ERBB1), ERBB2 (HER-2, NEU), FGFR3, H3-3A, H3C2, IDH1, IDH2, KIT (CD117), MDM2, MET, MLH1, MSH2, MTOR, MYC, NOTCH1, NRAS, PIK3CA (p110-alpha), PMS2, PTEN, RB1, STK11 (LKB1), TERT, TP53 (p53)
Gliomas
ACVR1 (ALK2), BRCA2, CHEK2 (RAD53), FGFR1, H3-3A, PDGFRA, PIK3CA (p110-alpha), PTEN, TP53 (p53)
High-Grade Gliomas
ATRX, BRAF, CIC, EGFR (ERBB1), FUBP1, IDH1, IDH2
Medulloblastomas
BRCA2, CDK4, CREBBP (CBP), CTNNB1, FGFR1, GLI2, IDH1, IDH2, MSH2, MYC, MYCN, NRAS, PIK3CA (p110-alpha), PTCH2, SMARCA4, SMARCB1, SUFU, TP53 (p53)
Meningiomas
CDKN2A (P16INK4A), CDKN2B (p15INK4b), NF2, PTEN
Oligodendrogliomas
IDH1, IDH2, MSH2, NOTCH1, TERT