PPP1R12C
PPP1R12C Gene Summary
The gene encodes a subunit of myosin phosphatase. The encoded protein regulates the catalytic activity of protein phosphatase 1 delta and assembly of the actin cytoskeleton. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]
Details
| Type | Protein Coding |
| Official Symbol | PPP1R12C |
| Official Name | protein phosphatase 1 regulatory subunit 12C [Source:HGNC Symbol;Acc:HGNC:14947] |
| Ensembl ID | ENSG00000125503 |
| Bio databases IDs | |
| Aliases | protein phosphatase 1 regulatory subunit 12C, myosin-binding subunit 85 |
| Synonyms | 2410197A17Rik,AAVS1,B430101M08,LENG3,MBS85,p84,p85,protein phosphatase 1 regulatory subunit 12C,protein phosphatase 1, regulatory subunit 12C |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cGMP-dependent protein kinase interacting domain
- Ankyrin repeats (many copies)
- tankyrase binding domain
- phosphatase
- Ankyrin repeats (3 copies)
- leucine zipper domain
- protein binding
- IPD_PPP1R12
- Ankyrin repeat
- ankyrin repeats
Pathways
Biological processes and signaling networks where the PPP1R12C gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- PPP1CC
- SOX2
- YWHAB
- BTF3
- PUM1
- NUAK1
- IL16
- YWHAH
- PPP1R12A
- SFN
disease
- preeclampsia
- infection by HIV-1
regulated by
- PRKAA2
- epithelial cells
- EZH2
- PRKCE
- trichostatin A
- PPP1R12C
- CCL2
- ROCK
- NRG2
- IL16
regulates
- PPP1R12C
- YWHAZ
- MRLC
role in cell
- phosphorylation in
- survival
- colony formation
- interaction in
- mitosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- actomyosin filament
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the PPP1R12C gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- signal transduction
CELLULAR COMPONENT
Where in the cell the gene product is active
- cytoplasm
- stress fiber
MOLECULAR FUNCTION
What the gene product does at the molecular level
- phosphatase regulator activity
- protein kinase binding
- protein binding
- enzyme inhibitor activity